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| Other names | LY-3437943 |
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Retatrutide (LY-3437943) is an experimental drug forobesity developed by the American pharmaceutical companyEli Lilly and Company. It is a tripleglucagon hormone receptor agonist (GLP-1, GIP, andGCGR receptors).[1][2][3]
Retatrutide has been studied in aphase 2 trial involving adults without diabetes but with obesity or preobesity (overweight).[4][5][6] Retatrutide is also being evaluated in phase 3 clinical trials.[7] A substudy in adults with type 2 diabetes reported differences in total body fat mass between study groups at 36 weeks.[8]
Across clinical studies, the most commonly reported adverse events were gastrointestinal symptoms such as nausea, vomiting, and diarrhea.[9]
Preclinical and biochemical studies describe receptor activity at GLP-1, GIP, and glucagon receptors.[10] Reports on its development state that it was engineered for activity across these targets.[11]
Systematic reviews and meta-analyses of randomized controlled trials report that retatrutide produces substantial reductions in body weight in adults with obesity, with mean percentage weight loss typically between 15 and 24 percent over 48 to 72 weeks, depending on study protocols and populations.[12][13][14][15][16] Adverse events are most commonly gastrointestinal symptoms such asnausea anddiarrhea, with relatively low rates of study discontinuation and infrequent serious adverse events reported during trials.[12][13][14] Safety assessments also indicate a low risk ofhypoglycemia and no significant elevation in cardiovascular or hepatic adverse events in non-diabetic populations across published studies.[15][16]
Retatrutide is apeptide with the followingamino acid sequence[17]
YA¹QGTFTSDYSIL²LDKK⁴AQA¹AFIEYLLEGGPSSGAPPPS³
where letters with superscripted numbers refer to the following chemical modifications: