Inrenal physiology,renal blood flow (RBF) is the volume ofblood delivered to the kidneys per unit time. In humans, the kidneys together receive roughly 20 - 25% ofcardiac output, amounting to 1.2 - 1.3 L/min in a healthy adult.^[1] It passes about 94% to the cortex. RBF is closely related torenal plasma flow (RPF), which is the volume ofblood plasma delivered to the kidneys per unit time.

While the terms generally apply toarterial blood delivered to the kidneys, both RBF and RPF can be used to quantify the volume ofvenous blood exiting the kidneys per unit time. In this context, the terms are commonly given subscripts to refer to arterial or venous blood or plasma flow, as in RBF_a, RBF_v, RPF_a, and RPF_v. Physiologically, however, the differences in these values are negligible so that arterial flow and venous flow are often assumed equal.

Renal plasma flow is the volume ofplasma that reaches the kidneys per unit time. Renal plasma flow is given by theFick principle:

${\displaystyle RPF=\frac{U_{x}V}{P_a-P_v}}$

This is essentially aconservation of mass equation which balances the renal inputs (therenal artery) and the renal outputs (therenal vein andureter). Put simply, a non-metabolizable solute entering the kidney via the renal artery has two points of exit, the renal vein and the ureter. The mass entering through the artery per unit time must equal the mass exiting through the vein and ureter per unit time:

${\displaystyle RP{F}_a\times P_a=RP{F}_v\times P_v+U_x\times V}$

whereP_a is the arterial plasma concentration of the substance,P_v is its venous plasma concentration,U_x is itsurine concentration, andV is the urine flow rate. The product of flow and concentration gives mass per unit time.

As mentioned previously, the difference between arterial and venous blood flow is negligible, soRPF_a is assumed to be equal toRPF_v, thus

${\displaystyle RPF\times P_a=RPF\times P_v+U_{x}V}$

Rearranging yields the previous equation for RPF:

${\displaystyle RPF=\frac{U_{x}V}{P_a-P_v}}$

Values ofP_v are difficult to obtain in patients. In practice,PAH clearance is used instead to calculate theeffective renal plasma flow (eRPF). PAH (para-aminohippurate) is freely filtered, is not reabsorbed, and is secreted within the nephron. In other words, not all PAH crosses into the primary filtrate in Bowman's capsule and the remaining PAH in the vasa recta or peritubular capillaries is taken up and secreted by epithelial cells of the proximal convoluted tubule into the tubule lumen. In this way PAH, at low doses, is almost completely cleared from the blood during a single pass through the kidney. (Accordingly, the plasma concentration of PAH in renal venous blood is approximately zero.) SettingP_v to zero in the equation for RPF yields

${\displaystyle eRPF=\frac{U_x}{P_a}V}$

which is the equation forrenal clearance. For PAH, this is commonly represented as

${\displaystyle eRPF=\frac{U_{PAH}}{P_{PAH}}V}$

Since the venous plasma concentration of PAH is not exactly zero (in fact, it is usually 10% of the PAH arterial plasma concentration), eRPF usually underestimates RPF by approximately 10%. This margin of error is generally acceptable considering the ease with which PAH infusion allows eRPF to be measured.

Finally, renal blood flow (RBF) can be calculated from a patient's renal plasma flow (RPF) andhematocrit (Hct) using the following equation:

${\displaystyle RBF=\frac{RPF}{1-Hct}}$.^[2]

If the kidney is methodologically perfused at moderate pressures (90–220 mm Hg performed on an experimental animal; in this case, a dog), then, there is a proportionate increase of:

-Renal Vascular Resistance

Along with the increase in pressure. At low perfusion pressures,Angiotensin II may act by constricting the efferent arterioles, thus mainlining the GFR and playing a role in autoregulation of renal blood flow.^[3] People with poor blood flow to the kidneys caused by medications that inhibit angiotensin-converting enzyme may facekidney failure.^[4]

Bibliography

• Renal Clearance TechniquesArchived 2013-12-24 at theWayback Machine

• Endocrine system anatomy
• Renal physiology

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