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Release modulator

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(Redirected fromRelease inhibitor)
Pharmaceutical

Arelease modulator, orneurotransmitter release modulator, is a type ofdrug thatmodulates therelease of one or moreneurotransmitters. Examples of release modulators includemonoamine releasing agents such as thesubstituted amphetamines (which induce the release ofnorepinephrine,dopamine, and/orserotonin)[1] andrelease inhibitors such asbotulinum toxin A (which inhibitsacetylcholine release by inactivatingSNAP-25, thereby preventingexocytosis from occurring).[2]

See also

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References

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  1. ^Rothman, RB; Baumann, MH; Dersch, CM; Romero, DV; Rice, KC; Carroll, FI; Partilla, JS (January 2001)."Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin".Synapse (New York, N.Y.).39 (1):32–41.doi:10.1002/1098-2396(20010101)39:1<32::AID-SYN5>3.0.CO;2-3.PMID 11071707. Retrieved21 August 2024.
  2. ^Montecucco, Cesare; Molgó, Jordi (June 2005). "Botulinal neurotoxins: revival of an old killer".Current Opinion in Pharmacology.5 (3):274–279.doi:10.1016/j.coph.2004.12.006.PMID 15907915.
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