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Relcovaptan

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Chemical compound

Pharmaceutical compound

Relcovaptan
Clinical data

Other names	(2S)-1-[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-(3,4-dimethoxyphenyl)sulfonyl-3-hydroxy-2H-indole-2-carbonyl]pyrrolidine-2-carboxamide
ATC code	none
Identifiers
IUPAC name 1-({(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)sulfonyl]-3-hydroxy-2,3-dihydro-1H-indol-2-yl}carbonyl)-L-prolinamide
CAS Number	150375-75-0^Y
PubChemCID	60943
IUPHAR/BPS	2200
ChemSpider	54910^N
UNII	C1GL8G6G0O
ChEMBL	ChEMBL419667^N
CompTox Dashboard(EPA)	DTXSID1045746
Chemical and physical data
Formula	C₂₈H₂₇Cl₂N₃O₇S
Molar mass	620.50 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COC1=C(C=C(C=C1)S(=O)(=O)N2[C@H]([C@](C3=C2C=CC(=C3)Cl)(C4=CC=CC=C4Cl)O)C(=O)N5CCC[C@H]5C(=O)N)OC
InChI InChI=1S/C28H27Cl2N3O7S/c1-39-23-12-10-17(15-24(23)40-2)41(37,38)33-21-11-9-16(29)14-19(21)28(36,18-6-3-4-7-20(18)30)25(33)27(35)32-13-5-8-22(32)26(31)34/h3-4,6-7,9-12,14-15,22,25,36H,5,8,13H2,1-2H3,(H2,31,34)/t22-,25-,28+/m0/s1^N Key:CEBYCSRFKCEUSW-NAYZPBBASA-N^N
^NY (what is this?) (verify)

Relcovaptan (SR-49059) is a non-peptide vasopressin receptor antagonist, selective for theV_1A subtype.^[1] It has shown positive initial results for the treatment ofRaynaud syndrome anddysmenorrhoea, and as atocolytic,^[2] although it is not yet approved for clinical use.

^Lemmens-Gruber R, Kamyar M (August 2006)."Vasopressin antagonists".Cellular and Molecular Life Sciences.63 (15):1766–79.doi:10.1007/s00018-006-6054-2.PMC 11136164.PMID 16794787.S2CID 30709102.
^Decaux G, Soupart A, Vassart G (May 2008). "Non-peptide arginine-vasopressin antagonists: the vaptans".Lancet.371 (9624):1624–32.doi:10.1016/S0140-6736(08)60695-9.PMID 18468546.S2CID 1245079.

V_1A	Agonists:Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists:Atosiban Balovaptan Conivaptan FR-218944 JNJ-17079166 JNJ-17308616 LIT-001 LY-307174 PF-184563 Relcovaptan RG7713 SRX246 SRX251 TC OT 39 WAY-267464 YM-218 YM-471 YM-35471
V_1B	Agonists:Desmopressin Felypressin Lypressin Ornipressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists:ABT-436 ABT-558 Brezivaptan Nelivaptan ORG-52186 (SCH-740935) TASP-0233278 TASP-0390325 Ligands:TASP-699
V₂	Agonists:Desmopressin Felypressin LIT-001 Lypressin Ornipressin TC OT 39 Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists:Conivaptan JNJ-17079166 Lixivaptan Mozavaptan RWJ-351647 Satavaptan Tolvaptan YM-471 YM-35471
Unsorted	Antagonists:Balovaptan Ribuvaptan RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors:Demeclocycline Lithium (lithium carbonate)

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