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Relaxin/insulin-like family peptide receptor 3

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

RXFP3

Identifiers

Aliases

RXFP3, GPCR135, RLN3R1, RXFPR3, SALPR, Relaxin/insulin-like family peptide receptor 3, relaxin/insulin like family peptide receptor 3, relaxin family peptide receptor 3

External IDs

OMIM:609445;MGI:2441827;HomoloGene:9568;GeneCards:RXFP3;OMA:RXFP3 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5p13.2	Start	33,936,386bp^[1]
Band	5p13.2	End	33,938,918bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15\|15 A1	Start	11,033,803bp^[2]
Band	15\|15 A1	End	11,038,077bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

islet of Langerhans

right adrenal cortex

left adrenal cortex

prefrontal cortex

superior frontal gyrus

anterior pituitary

hypothalamus

caudate nucleus

substantia nigra

head

Top expressed in

embryo

dentate gyrus of hippocampal formation granule cell

embryo

hippocampus proper

hypothalamus

visual cortex

neural tube

mesencephalon

neural layer of retina

primary visual cortex

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	G protein-coupled receptor activity signal transducer activity galanin receptor activity G protein-coupled peptide receptor activity
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane
Biological process	positive regulation of cytokinesis G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway signal transduction adenylate cyclase-modulating G protein-coupled receptor signaling pathway neuropeptide signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


51289


239336

Ensembl


ENSG00000182631 ENSG00000277069


ENSMUSG00000060735

UniProt


Q9NSD7


Q8BGE9

RefSeq (mRNA)


NM_016568


NM_178717

RefSeq (protein)


NP_057652


NP_848832

Location (UCSC)

Chr 5: 33.94 – 33.94 Mb

Chr 15: 11.03 – 11.04 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Relaxin/insulin-like family peptide receptor 3, also known asRXFP3, is a humanG-protein coupled receptor.^[5]

References

[edit]

^^a ^b ^cENSG00000277069 GRCh38: Ensembl release 89: ENSG00000182631, ENSG00000277069 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000060735 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: RXFP3 relaxin/insulin-like family peptide receptor 3".

External links

[edit]

"Relaxin Family Peptide Receptors: RXFP3".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2008-12-09.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)