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Relacorilant

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Relacorilant
Clinical data
Other namesCORT-125134
Routes of
administration
By mouth
Drug classAntiglucocorticoid
Identifiers
  • [(4aR)-1-(4-Fluorophenyl)-6-(1-methylpyrazol-4-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
Chemical and physical data
FormulaC27H22F4N6O3S
Molar mass586.57 g·mol−1
3D model (JSmol)
  • CN1C=C(C=N1)S(=O)(=O)N2CCC3=CC4=C(C[C@@]3(C2)C(=O)C5=NC=CC(=C5)C(F)(F)F)C=NN4C6=CC=C(C=C6)F
  • InChI=1S/C27H22F4N6O3S/c1-35-15-22(14-33-35)41(39,40)36-9-7-18-11-24-17(13-34-37(24)21-4-2-20(28)3-5-21)12-26(18,16-36)25(38)23-10-19(6-8-32-23)27(29,30)31/h2-6,8,10-11,13-15H,7,9,12,16H2,1H3/t26-/m0/s1
  • Key:WANIDIGFXJFFEL-SANMLTNESA-N

Relacorilant (developmental code nameCORT-125134) is anantiglucocorticoid which is under development by Corcept Therapeutics for the treatment ofCushing's syndrome.[1] It is also under development for the treatment ofsolid tumors andalcoholism.[1][2] The drug is anonsteroidalcompound and acts as anantagonist of theglucocorticoid receptor.[1] As of December 2017, it is inphase IIclinical trials for Cushing's syndrome andphase I/II clinical studies for solid tumors, while the clinical phase for alcoholism is unknown.[1]

See also

[edit]

References

[edit]
  1. ^abcd"Relacorilant - Corcept Therapeutics - AdisInsight".
  2. ^Veneris JT, Darcy KM, Mhawech-Fauceglia P, Tian C, Lengyel E, Lastra RR, Pejovic T, Conzen SD, Fleming GF (2017)."High glucocorticoid receptor expression predicts short progression-free survival in ovarian cancer".Gynecol. Oncol.146 (1):153–160.doi:10.1016/j.ygyno.2017.04.012.PMC 5955699.PMID 28456378.

External links

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GRTooltip Glucocorticoid receptor
Agonists
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others


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