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Razi Cov Pars

From Wikipedia, the free encyclopedia
Vaccine candidate against COVID-19

Pharmaceutical compound
Razi Cov Pars
Vaccine description
TargetSARS-CoV-2
Vaccine typeProtein subunit
Clinical data
Routes of
administration
Intramuscular,Intranasal
Legal status
Legal status
Identifiers
CAS Number
Part ofa series on the
COVID-19 pandemic
Scientifically accurate atomic model of the external structure of SARS-CoV-2. Each "ball" is an atom.
Scientifically accurate atomic model of the external structure of SARS-CoV-2. Each "ball" is an atom.
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Razi Cov Pars (Persian:رازی کوو پارس) is aCOVID-19 vaccine developed by the IranianRazi Vaccine and Serum Research Institute Razi Cov Pars is a covid-19 vaccine based on recombinant protein, which is being produced by Razi Vaccine and Serum Research Institute, Iran. This vaccine is the first injectable-intranasal recombinant protein corona vaccine.[1][2][3]It's the second Iranian COVID-19 vaccine reaching human trials[1] and is currently inphase III ofclinical research during which it's compared to theSinopharm BIBP vaccine.[4][5]

Medical uses

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It requires three doses given day 0 (intramuscular), day 21 (intramuscular) and day 51 (intranasal spray).[3]

Pharmacology

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Razi Cov Pars is arecombinant proteinsubunit vaccine containing the SARS-CoV-2spike protein.[2]

Manufacturing

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It's planned to produce one million doses of the vaccine each month as of September 2021.[4]

As of 25 November 2021, 5 millions doses have been delivered to theIranian Ministry of Health.[6]

History

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Clinical trials

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Clinical trials of Razi Cov Pars
PhaseRegistration numberStartNumber of participantsAge of participantsRef
TotalVaccinePlacebo
IIRCT20201214049709N121 January 202113330(5 μg/200 μL)

30(10 μg/200 μL)

30(20 μg/200 μL)

30(placebo)

13(sentinel)

18-50 years[2]
IIIRCT20201214049709N213 April 202150018-70 years[3]
IIIIRCT20201214049709N3Archived 30 August 2021 at theWayback Machine29 August 202141,12820,5640(placebo)

20,564(Sinopharm BIBP vaccine)

18+ years[5]

See also

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References

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  1. ^abBanihashemi SR, Es-Haghi A, Fallah Mehrabadi MH, Nofeli M, Mokarram AR, Ranjbar A, et al. (26 May 2022)."Safety and Efficacy of Combined Intramuscular/Intranasal RAZI-COV PARS Vaccine Candidate Against SARS-CoV-2: A Preclinical Study in Several Animal Models".Frontiers in Immunology.13 836745.doi:10.3389/fimmu.2022.836745.PMC 9179012.PMID 35693788.
  2. ^abc"Phase I, Safety and Immunogenicity of Razi SARS-CoV-2 recombinant Spike protein vaccine (Razi Cov Pars), in healthy adults aged 18-55 years; parallel 4 arms design (adjuvant only and three vaccine doses of 5, 10, and 20 μg/200 μL); a Randomised, double blind, clinical trial".irct.ir. Iranian Registry of Clinical Trials. Retrieved21 March 2021.
  3. ^abc"Phase II, Safety and Immunogenicity of RAZI SARS-CoV-2 recombinant Spike protein vaccine (RAZI Cov Pars) in adults aged 18-70 years; a Randomised, double blind, parallel 2 arms clinical trial". Iranian Registry of Clinical Trials. Retrieved22 April 2021.
  4. ^ab"COVID-19 vaccine Razi Cov Pars starts third clinical trial phase".Tehran Times. 27 August 2021. Retrieved30 August 2021.
  5. ^ab"IRCT | Comparison of the safety and efficacy of Razi SARS-CoV-2 recombinant Spike protein (Razi Cov Pars) and Sinopharm vaccines in adults aged 18 and over, a phase III randomised, double blind, non-inferiority clinical trial".en.irct.ir. Archived fromthe original on 30 August 2021. Retrieved30 August 2021.
  6. ^"۵ میلیون دز واکسن رازی به وزارت بهداشت تحویل داده شد" [5 million doses of Razi vaccine were delivered to the Ministry of Health].ایسنا(ISNA) (in Persian). 25 November 2021. Retrieved27 November 2021.

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