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Radequinil

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Chemical compound

Pharmaceutical compound

Radequinil
Clinical data

ATC code	None
Identifiers
IUPAC name 5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-1,6-naphthyridin-2(1H)-one
CAS Number	219846-31-8
PubChemCID	22714308
ChemSpider	11584471
UNII	2G222T03EY
CompTox Dashboard(EPA)	DTXSID60944577
Chemical and physical data
Formula	C₁₈H₁₄N₄O₃
Molar mass	334.335 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COc1cccc(c1)c3nccc2NC(=O)\C(=C/c23)c4nc(C)on4
InChI InChI=1S/C18H14N4O3/c1-10-20-17(22-25-10)14-9-13-15(21-18(14)23)6-7-19-16(13)11-4-3-5-12(8-11)24-2/h3-9H,1-2H3,(H,21,23) Key:JQOFKKWHXGQABB-UHFFFAOYSA-N

Radequinil (INN;AC-3933) is acognitive enhancer which acts as a partialinverse agonist of thebenzodiazepine site of theGABA_A receptor.^[1] It was under development byDainippon Sumitomo Pharma for the treatment ofAlzheimer's disease and made it tophase II clinical trials but development seems to have been halted and it was never marketed.^[1]^[2]

See also

References

^^a ^bMartocchia A, Falaschi P (2008)."Current Strategies of Therapy in Alzheimer's Disease"(PDF).The Open Neuropsychopharmacology Journal.1:19–23.doi:10.2174/1876523800801010019.
^Pogacić V, Herrling P (2007)."List of drugs in development for neurodegenerative diseases. Update June 2007".Neuro-Degenerative Diseases.4 (6):443–86.doi:10.1159/000107705.PMID 17934328.

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GABA receptor modulators

GABA_ATooltip γ-Aminobutyric acid A receptor

Positive modulators (abridged; seehere for a full list):α-EMTBL
Alcohols (e.g.,drinking alcohol,2M2B)
Anabolic steroids
Avermectins (e.g.,ivermectin)
Barbiturates (e.g.,phenobarbital)
Benzodiazepines (e.g.,diazepam)
Bromide compounds (e.g.,potassium bromide)
Carbamates (e.g.,meprobamate)
Carbamazepine
Chloralose
Chlormezanone
Clomethiazole
Dihydroergolines (e.g.,ergoloid (dihydroergotoxine))
Etazepine
Etifoxine
Fenamates (e.g.,mefenamic acid)
Flavonoids (e.g.,apigenin,hispidulin)
Fluoxetine
Flupirtine
Imidazoles (e.g.,etomidate)
Kava constituents (e.g.,kavain)
Lanthanum
Loreclezole
Monastrol
Neuroactive steroids (e.g.,allopregnanolone,cholesterol,THDOC)
Niacin
Niacinamide
Nonbenzodiazepines (e.g.,β-carbolines (e.g.,abecarnil),cyclopyrrolones (e.g.,zopiclone),imidazopyridines (e.g.,zolpidem),pyrazolopyrimidines (e.g.,zaleplon))
Norfluoxetine
Petrichloral
Phenols (e.g.,propofol)
Phenytoin
Piperidinediones (e.g.,glutethimide)
Propanidid
Pyrazolopyridines (e.g.,etazolate)
Quinazolinones (e.g.,methaqualone)
Retigabine (ezogabine)
ROD-188
Skullcap constituents (e.g.,baicalin)
Stiripentol
Sulfonylalkanes (e.g.,sulfonmethane (sulfonal))
Topiramate
Valerian constituents (e.g.,valerenic acid)
Volatiles/gases (e.g.,chloral hydrate,chloroform,diethyl ether,paraldehyde,sevoflurane)

GABA_A-ρTooltip γ-Aminobutyric acid A-rho receptor

Negative modulators:5α-Dihydroprogesterone
Bilobalide
Loreclezole
Picrotoxin (picrotin,picrotoxinin)
Pregnanolone
ROD-188
THDOC
Zinc

GABA_BTooltip γ-Aminobutyric acid B receptor

Negative modulators:Compound 14

See also: Receptor/signaling modulators; GABA_A receptor positive modulators; GABA metabolism/transport modulators

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