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RUNX1T1

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From Wikipedia, the free encyclopedia

Protein-coding gene in humans

RUNX1T1

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
1WQ6,2DJ8,2H7B,2KYG,2OD1,2ODD,2PP4,4JOL

Identifiers

Aliases

RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2, AML1-MTG8, t(8;21)(q22;q22), RUNX1 translocation partner 1, RUNX1 partner transcriptional co-repressor 1

External IDs

OMIM:133435;MGI:104793;HomoloGene:3801;GeneCards:RUNX1T1;OMA:RUNX1T1 - orthologs

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8q21.3	Start	91,954,967bp^[1]
Band	8q21.3	End	92,103,286bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4 A1\|4 5.88 cM	Start	13,743,436bp^[2]
Band	4 A1\|4 5.88 cM	End	13,893,649bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

sural nerve

buccal mucosa cell

tendon of biceps brachii

Brodmann area 23

Achilles tendon

paraflocculus of cerebellum

middle temporal gyrus

epithelium of colon

parietal pleura

Top expressed in

Rostral migratory stream

secondary oocyte

zygote

internal carotid artery

genital tubercle

external carotid artery

olfactory tubercle

ascending aorta

mammillary body

lateral hypothalamus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA-binding transcription factor activity DNA binding protein binding transcription corepressor activity metal ion binding
Cellular component	nuclear matrix nucleus nucleoplasm
Biological process	negative regulation of fat cell differentiation negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated generation of precursor metabolites and energy transcription, DNA-templated
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


862


12395

Ensembl


ENSG00000079102


ENSMUSG00000006586

UniProt


Q06455


Q61909

RefSeq (mRNA)

NM_001198625 NM_001198626 NM_001198627 NM_001198628 NM_001198629
NM_001198630 NM_001198631 NM_001198632 NM_001198633 NM_001198634 NM_001198679 NM_004349 NM_175634 NM_175635 NM_175636 NM_001395209


NM_001111026 NM_001111027 NM_009822

RefSeq (protein)

NP_001185554 NP_001185555 NP_001185556 NP_001185557 NP_001185558
NP_001185559 NP_001185560 NP_001185561 NP_001185562 NP_001185563 NP_001185608 NP_004340 NP_783552 NP_783553 NP_783554 NP_783553.1 NP_783554.1


NP_001104496 NP_001104497 NP_033952

Location (UCSC)

Chr 8: 91.95 – 92.1 Mb

Chr 4: 13.74 – 13.89 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Protein CBFA2T1 is aprotein that in humans is encoded by theRUNX1T1gene.^[5]^[6]^[7]

Function

[edit]

The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. Inacute myeloid leukemia, especially in theM2 subtype, the t(8;21)(q22;q22)translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the5′-region of theRUNX1 gene fused to the 3′-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.^[7]

Interactions

[edit]

RUNX1T1 has been shown tointeract with:

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000079102 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000006586 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Erickson P, Gao J, Chang KS, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley J, Drabkin H (October 1992)."Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt".Blood.80 (7):1825–31.doi:10.1182/blood.V80.7.1825.1825.PMID 1391946.
^Calabi F, Cilli V (Dec 1998). "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family".Genomics.52 (3):332–341.doi:10.1006/geno.1998.5429.PMID 9790752.
^^a ^b"Entrez Gene: RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)".
^Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437 (7062):1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID 16189514.S2CID 4427026.
^^a ^bLindberg SR, Olsson A, Persson AM, Olsson I (Dec 2003). "Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins".Eur. J. Haematol.71 (6):439–47.doi:10.1046/j.0902-4441.2003.00166.x.PMID 14703694.S2CID 23106882.
^^a ^bHoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N (September 2002)."The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies".Oncogene.21 (43):6703–12.doi:10.1038/sj.onc.1205882.PMID 12242670.
^Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M (Dec 2002). "AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor".Cancer Res.62 (23):7050–8.PMID 12460926.
^McGhee L, Bryan J, Elliott L, Grimes HL, Kazanjian A, Davis JN, Meyers S (August 2003). "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism".J. Cell. Biochem.89 (5):1005–18.doi:10.1002/jcb.10548.PMID 12874834.S2CID 25450754.
^Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW (October 2001)."ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain".Mol. Cell. Biol.21 (19):6470–83.doi:10.1128/mcb.21.19.6470-6483.2001.PMC 99794.PMID 11533236.
^^a ^bZhang J, Hug BA, Huang EY, Chen CW, Gelmetti V, Maccarana M, Minucci S, Pelicci PG, Lazar MA (January 2001)."Oligomerization of ETO is obligatory for corepressor interaction".Mol. Cell. Biol.21 (1):156–63.doi:10.1128/MCB.21.1.156-163.2001.PMC 88789.PMID 11113190.
^Takahashi S, McConnell MJ, Harigae H, Kaku M, Sasaki T, Melnick AM, Licht JD (June 2004)."The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT".Blood.103 (12):4650–8.doi:10.1182/blood-2003-08-2759.PMID 14982881.
^Fukuyama T, Sueoka E, Sugio Y, Otsuka T, Niho Y, Akagi K, Kozu T (September 2001)."MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes".Oncogene.20 (43):6225–32.doi:10.1038/sj.onc.1204794.PMID 11593431.
^Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD (March 2000)."The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein".Mol. Cell. Biol.20 (6):2075–86.doi:10.1128/mcb.20.6.2075-2086.2000.PMC 110824.PMID 10688654.
^Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD (Dec 2000). "AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein".Blood.96 (12):3939–47.doi:10.1182/blood.V96.12.3939.PMID 11090081.

Ferrara F, Del Vecchio L (2002). "Acute myeloid leukemia with t(8;21)/AML1/ETO: a distinct biological and clinical entity".Haematologica.87 (3):306–19.PMID 11869944.
Nisson PE, Watkins PC, Sacchi N (1992). "Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells".Cancer Genet. Cytogenet.63 (2):81–88.doi:10.1016/0165-4608(92)90384-K.PMID 1423235.
Era T, Asou N, Kunisada T, Yamasaki H, Asou H, Kamada N, Nishikawa S, Yamaguchi K, Takatsuki K (1995). "Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells".Genes Chromosomes Cancer.13 (1):25–33.doi:10.1002/gcc.2870130105.PMID 7541640.S2CID 41918020.
Tighe JE, Calabi F (1994)."Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2".Blood.84 (7):2115–21.doi:10.1182/blood.V84.7.2115.2115.PMID 7919324.
Erickson PF, Robinson M, Owens G, Drabkin HA (1994). "The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor".Cancer Res.54 (7):1782–6.PMID 8137293.
Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, Kamada N, Ohki M (1993)."The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript".EMBO J.12 (7):2715–21.doi:10.1002/j.1460-2075.1993.tb05933.x.PMC 413521.PMID 8334990.
Kozu T, Miyoshi H, Shimizu K, Maseki N, Kaneko Y, Asou H, Kamada N, Ohki M (1993)."Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction".Blood.82 (4):1270–6.doi:10.1182/blood.V82.4.1270.1270.PMID 8353289.
Niwa-Kawakita M, Miyoshi H, Gotoh O, Matsushima Y, Nishimura M, Shisa H, Ohki M (1996). "Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia".Genomics.29 (3):755–759.doi:10.1006/geno.1995.9941.PMID 8575770.
Erickson PF, Dessev G, Lasher RS, Philips G, Robinson M, Drabkin HA (1996)."ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease".Blood.88 (5):1813–23.doi:10.1182/blood.V88.5.1813.1813.PMID 8781439.
Wolford JK, Bogardus C, Prochazka M (1998)."Polymorphism in the 3' untranslated region of MTG8 is associated with obesity in Pima Indian males".Biochem. Biophys. Res. Commun.246 (3):624–626.Bibcode:1998BBRC..246..624W.doi:10.1006/bbrc.1998.8683.PMID 9618262.
Sacchi N, Tamanini F, Willemsen R, Denis-Donini S, Campiglio S, Hoogeveen AT (1998)."Subcellular localization of the oncoprotein MTG8 (CDR/ETO) in neural cells".Oncogene.16 (20):2609–2615.doi:10.1038/sj.onc.1201824.PMID 9632137.
Wolford JK, Prochazka M (1998). "Structure and expression of the human MTG8/ETO gene".Gene.212 (1):103–109.doi:10.1016/S0378-1119(98)00141-3.PMID 9661669.
Komori A, Sueoka E, Fujiki H, Ishii M, Kozu T (1999)."Association of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines".Jpn. J. Cancer Res.90 (1):60–8.doi:10.1111/j.1349-7006.1999.tb00666.x.PMC 5925983.PMID 10076566.
Morohoshi F, Mitani S, Mitsuhashi N, Kitabayashi I, Takahashi E, Suzuki M, Munakata N, Ohki M (2000). "Structure and expression pattern of a human MTG8/ETO family gene, MTGR1".Gene.241 (2):287–295.doi:10.1016/S0378-1119(99)00481-3.PMID 10675041.
Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD (2000)."The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein".Mol. Cell. Biol.20 (6):2075–2086.doi:10.1128/MCB.20.6.2075-2086.2000.PMC 110824.PMID 10688654.
Miyamoto T, Weissman IL, Akashi K (2000)."AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation".Proc. Natl. Acad. Sci. U.S.A.97 (13):7521–7526.Bibcode:2000PNAS...97.7521M.doi:10.1073/pnas.97.13.7521.PMC 16578.PMID 10861016.
Odaka Y, Mally A, Elliott LT, Meyers S (2000)."Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8)".Oncogene.19 (32):3584–3597.doi:10.1038/sj.onc.1203689.PMID 10951564.
Wood JD, Nucifora FC, Duan K, Zhang C, Wang J, Kim Y, Schilling G, Sacchi N, Liu JM, Ross CA (2000)."Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription".J. Cell Biol.150 (5):939–948.doi:10.1083/jcb.150.5.939.PMC 2175251.PMID 10973986.

v t e PDB gallery
1wq6: The tetramer structure of the nervy homology two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity 2dj8: Solution Structure of zf-MYND Domain of Protein CBFA2TI (Protein MTG8) 2h7b: Solution structure of the eTAFH domain from the human leukemia-associated fusion protein AML1-ETO

Transcription factors andintracellular receptors

(1) Basic domains

(1.1) Basicleucine zipper (bZIP)

Activating transcription factor
- AATF
- 1
- 2
- 3
- 4
- 5
- 6
- 7
AP-1
- c-Fos
- FOSB
- FOSL1
- FOSL2
- JDP2
- c-Jun
- JUNB
- JunD
BACH
- 1
- 2
BATF
BLZF1
C/EBP
- α
- β
- γ
- δ
- ε
- ζ
CREB
- 1
- 3
- L1
CREM
DBP
DDIT3
GABPA
GCN4
HLF
MAF
- B
- sMaf
  - F
  - G
  - K
NFE
- 2
- L1
- L2
- L3
NFIL3
NRL
NRF
- 1
- 2
- 3
XBP1

(1.2) Basic helix-loop-helix (bHLH)

Group A	AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5 MYF6 NeuroD 1 2 Neurogenins 1 2 3 OLIG 1 2 Paraxis TCF15 Scleraxis SLC LYL1 TAL 1 2 Twist
Group B	FIGLA Myc c-Myc l-Myc n-Myc MXD4 TCF4
Group C bHLH-PAS	AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2
Group D	BHLH 2 3 9 Pho4 ID 1 2 3 4
Group E	HES 1 2 3 4 5 6 7 HEY 1 2 L
Group F bHLH-COE	EBF1

(1.3)bHLH-ZIP

(1.4) NF-1

NFI
- A
- B
- C
- X
SMAD
- R-SMAD
  - 1
  - 2
  - 3
  - 5
  - 9
- I-SMAD
  - 6
  - 7
- 4)

(1.5) RF-X

RFX
- 1
- 2
- 3
- 4
- 5
- 6
- ANK

(1.6) Basic helix-span-helix (bHSH)

AP-2
- α
- β
- γ
- δ
- ε

(2)Zinc finger DNA-binding domains

(2.1)Nuclear receptor(Cys₄)

subfamily 1	Thyroid hormone α β CAR FXR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR
subfamily 2	COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular receptor 2 4 TLX
subfamily 3	Steroid hormone Androgen Estrogen α β Glucocorticoid Mineralocorticoid Progesterone Estrogen related α β γ
subfamily 4	NUR NGFIB NOR1 NURR1
subfamily 5	LRH-1 SF1
subfamily 6	GCNF
subfamily 0	DAX1 SHP

(2.2) Other Cys₄

GATA
- 1
- 2
- 3
- 4
- 5
- 6
MTA
- 1
- 2
- 3
TRPS1

(2.3) Cys₂His₂

General transcription factors
- TFIIA
- TFIIB
- TFIID
- TFIIE
  - 1
  - 2
- TFIIF
- 1
- 2
  - TFIIH
  - 1
  - 2
  - 4
  - 2I
  - 3A
  - 3C1
  - 3C2

ATBF1
BCL
- 6
- 11A
- 11B
CTCF
E4F1
EGR
- 1
- 2
- 3
- 4
ERV3
GFI1
GLI family
- 1
- 2
- 3
- REST
- S1
- S2
- YY1
HIC
- 1
- 2
HIVEP
- 1
- 2
- 3
IKZF
- 1
- 2
- 3
ILF
- 2
- 3
Sp/KLF family
- KLF
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - 7
  - 8
  - 9
  - 10
  - 11
  - 12
  - 13
  - 14
  - 15
  - 17
- SP
  - 1
  - 2
  - 4
  - 7
  - 8
MTF1
MYT1
OSR1
PRDM9
SALL
- 1
- 2
- 3
- 4
TSHZ3
WT1
Zbtb7
- 7A
- 7B
ZBTB
- 11
- 16
- 17
- 20
- 21
- 32
- 33
- 40
zinc finger
- 3
- 7
- 9
- 10
- 19
- 22
- 24
- 33B
- 34
- 35
- 41
- 43
- 44
- 51
- 74
- 143
- 146
- 148
- 165
- 202
- 217
- 219
- 238
- 239
- 259
- 267
- 268
- 281
- 300
- 318
- 330
- 346
- 350
- 365
- 366
- 384
- 423
- 451
- 452
- 471
- 593
- 638
- 644
- 649
- 655
- 804A

(2.4) Cys₆

HIVEP1

(2.5) Alternating composition

AIRE
DIDO1
GRLF1
ING
- 1
- 2
- 4
JARID
- 1A
- 1B
- 1C
- 1D
- 2
JMJD1B

(2.6) WRKY

WRKY

(3)Helix-turn-helixdomains

(3.1)Homeodomain

Antennapedia
ANTP class

protoHOX Hox-like	ParaHox Gsx 1 2 Xlox PDX1 Cdx 1 2 4 extended Hox:Evx1 Evx2 MEOX1 MEOX2 Homeobox A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 GBX1 GBX2 MNX1
metaHOX NK-like	BARHL1 BARHL2 BARX1 BARX2 BSX DBX 1 2 DLX 1 2 3 4 5 6 EMX 1 2 EN 1 2 HHEX HLX LBX1 LBX2 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 HMX1 HMX2 HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2

other

ARX
CRX
CUTL1
FHL
- 1
- 2
- 3
HESX1
HOPX
LMX
- 1A
- 1B
NOBOX
TALE
- IRX
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - MKX
- MEIS
  - 1
  - 2
- PBX
  - 1
  - 2
  - 3
- PKNOX
  - 1
  - 2
- SIX
  - 1
  - 2
  - 3
  - 4
  - 5
PHF
- 1
- 3
- 6
- 8
- 10
- 16
- 17
- 20
- 21A
POU domain
- PIT-1
- BRN-3:A
- B
- C
- Octamer transcription factor:1
- 2
- 3/4
- 6
- 7
- 11
SATB2
ZEB
- 1
- 2

(3.2) Paired box

PAX
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
PRRX
- 1
- 2
PROP1
PHOX
- 2A
- 2B
RAX
SHOX
SHOX2
VSX1
VSX2
Bicoid
- GSC
- BICD2
- OTX
  - 1
  - 2
- PITX
  - 1
  - 2
  - 3

(3.3)Fork head /winged helix

E2F
- 1
- 2
- 3
- 4
- 5
FOX proteins
- A1
- A2
- A3
- B1
- B2
- C1
- C2
- D1
- D2
- D3
- D4
- D4L1
- D4L3
- D4L4
- D4L5
- D4L6
- E1
- E3
- F1
- F2
- G1
- H1
- I1
- I2
- I3
- J1
- J2
- J3
- K1
- K2
- L1
- L2
- M1
- N1
- N2
- N3
- N4
- O1
- O3
- O4
- O6
- P1
- P2
- P3
- P4
- Q1
- R1
- R2
- S1

(3.4)Heat shock factors

HSF
- 1
- 2
- 4

(3.5) Tryptophan clusters

ELF
- 2
- 4
- 5
EHF
ELK
- 1
- 3
- 4
ERF
ETS
- 1
- 2
- ERG
- SPIB
ETV
- 1
- 4
- 5
- 6
FLI1
Interferon regulatory factors
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
MYB
MYBL2

(3.6) TEA domain

transcriptional enhancer factor
- 1
- 2
- 3
- 4

(4)β-Scaffold factors with minor groove contacts

(4.1)Rel homology region	NF-κB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5
(4.2)STAT	STAT 1 2 3 4 5 6
(4.3) p53-like	p53 p63 p73 family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF
(4.4)MADS box	Mef2 A B C D SRF
(4.6)TATA-binding proteins	TBP TBPL1
(4.7)High-mobility group	BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 17 18 21 SRY SSRP1 TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4
(4.9) Grainyhead	TFCP2
(4.10) Cold-shock domain	CSDA YBX1
(4.11) Runt	CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA 1 2 HBP1
(0.3)Pocket domain	Rb RBL1 RBL2
(0.5)AP-2/EREBP-related factors	Apetala 2 EREBP B3
(0.6) Miscellaneous	ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma

see alsotranscription factor/coregulator deficiencies

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[8]ページ先頭

Movatterモバイル変換

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