The drug producesMDMA-likelocomotor hyperactivity in animals and this is thought to be mediated by activation of both serotonin 5-HT1A and 5-HT1B receptors.[6][1][7][8][9] As with other serotonin 5-HT1B receptor agonists such asCP-94,253, RU-24,969 has also been found to increase thereinforcing properties ofcocaine in animals, suggesting a role for serotonin 5-HT1B receptors incocaine addiction as well.[10] The drug producesantiaggressive effects in rodents.[11][12][13]
^abcMartinez-Price D, Krebs-Thomson K, Geyer M (1 January 2002). "Behavioral Psychopharmacology of MDMA and MDMA-Like Drugs: A Review of Human and Animal Studies".Addiction Research & Theory.10 (1). Informa UK Limited:43–67.doi:10.1080/16066350290001704.ISSN1606-6359.
^abDoods HN, Kalkman HO, De Jonge A, Thoolen MJ, Wilffert B, Timmermans PB, et al. (June 1985). "Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity".European Journal of Pharmacology.112 (3):363–370.doi:10.1016/0014-2999(85)90782-4.PMID3160596.
^Glennon RA (January 1987). "Central serotonin receptors as targets for drug research".J Med Chem.30 (1):1–12.doi:10.1021/jm00384a001.PMID3543362.Table II. Affinities of Selected Phenalkylamines for 5-HT1 and 5-HT2 Binding Sites
^McDougall SA, Robinson JA, Ramirez EL, Diaz HA (February 2020). "Serotonin 5-HT1A and 5-HT1B receptors co-mediate the RU 24969-induced locomotor activity of male and female preweanling rats".Pharmacology, Biochemistry, and Behavior.189 172857.doi:10.1016/j.pbb.2020.172857.PMID31958472.
^Liechti ME, Vollenweider FX (December 2001). "Which neuroreceptors mediate the subjective effects of MDMA in humans? A summary of mechanistic studies".Human Psychopharmacology.16 (8):589–598.doi:10.1002/hup.348.PMID12404538.
^Rempel NL, Callaway CW, Geyer MA (May 1993). "Serotonin1B receptor activation mimics behavioral effects of presynaptic serotonin release".Neuropsychopharmacology.8 (3):201–211.doi:10.1038/npp.1993.22.PMID8099482.
^Scearce-Levie K, Viswanathan SS, Hen R (January 1999). "Locomotor response to MDMA is attenuated in knockout mice lacking the 5-HT1B receptor".Psychopharmacology.141 (2):154–161.doi:10.1007/s002130050819.PMID9952039.
^Olivier B, Mos J (1992). "Rodent models of aggressive behavior and serotonergic drugs".Prog Neuropsychopharmacol Biol Psychiatry.16 (6):847–870.doi:10.1016/0278-5846(92)90104-m.PMID1513929.
^Sánchez C, Arnt J, Hyttel J, Moltzen EK (1993). "The role of serotonergic mechanisms in inhibition of isolation-induced aggression in male mice".Psychopharmacology (Berl).110 (1–2):53–59.doi:10.1007/BF02246950.PMID7870899.
^Olivier B, Mos J, van Oorschot R, Hen R (October 1995). "Serotonin receptors and animal models of aggressive behavior".Pharmacopsychiatry. 28 Suppl 2:80–90.doi:10.1055/s-2007-979624.PMID8614705.
^Euvrard C, Boissier JR (April 1980). "Biochemical assessment of the central 5-HT agonist activity of RU 24969 (a piperidinyl indole)".European Journal of Pharmacology.63 (1):65–72.doi:10.1016/0014-2999(80)90117-x.PMID6155275.
