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| Formula | C20H27NO2 |
| Molar mass | 313.441 g·mol−1 |
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RTI(-4229)-150, ((−)-2β-Carbocyclobutoxy-3β-(4-methylphenyl)tropane) is aphenyltropane derivative which acts as a potentdopamine reuptake inhibitor andstimulant drug. It is around 5x more potent thancocaine, but is more selective for thedopamine transporter relative to the other monoamine transporters. RTI-150 has a fast onset of effects and short duration of action, and itsabuse potential in animal studies is similar to that of cocaine itself; its main application in scientific research has been in studies investigating the influence ofpharmacokinetics on the abuse potential of stimulant drugs, with the rapid entry of RTI-150 into the brain thought to be a key factor in producing its high propensity for development of dependence in animals.[1][2][3] RTI-150 is not explicitly illegal anywhere in the world, but its similar structure and pharmacological activity to cocaine makes it possible that it would be considered acontrolled substance analogue in countries such as the US, Canada, Australia and New Zealand which have controlled substance analogue legislation.
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