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RJR-2429

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Chemical compound

Pharmaceutical compound

RJR-2429
Identifiers

CAS Number	91556-75-1
PubChemCID	10176454
ChemSpider	8351959
UNII	Q2L6T24QLT
CompTox Dashboard(EPA)	DTXSID40436425
Chemical and physical data
Formula	C₁₂H₁₆N₂
Molar mass	188.274 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1(C2N(CC3)CCC3C2)=CN=CC=C1
InChI InChI=1S/C12H16N2/c1-2-11(9-13-5-1)12-8-10-3-6-14(12)7-4-10/h1-2,5,9-10,12H,3-4,6-8H2 Key:YJYPZLAZNIGNRP-UHFFFAOYSA-N

RJR-2429 is a drug that acts as anagonist at neuralnicotinic acetylcholine receptors, binding to both theα3β4 and theα4β2 subtypes. RJR-2429 is stronger thannicotine but weaker thanepibatidine in most assays, and with high affinity for both α3β4 and α4β2 subtypes, as well as the less studied α1βγδ subtype.^[1]^[2]^[3]

^Bencherif M, Schmitt JD, Bhatti BS, Crooks P, Caldwell WS, Lovette ME, et al. (March 1998). "The heterocyclic substituted pyridine derivative (+/-)-2-(-3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors".The Journal of Pharmacology and Experimental Therapeutics.284 (3):886–94.PMID 9495846.
^Yokotani K, Okada S, Nakamura K (June 2002). "Characterization of functional nicotinic acetylcholine receptors involved in catecholamine release from the isolated rat adrenal gland".European Journal of Pharmacology.446 (1–3):83–7.doi:10.1016/s0014-2999(02)01819-8.PMID 12098588.
^Bhatti BS, Strachan JP, Breining SR, Miller CH, Tahiri P, Crooks PA, et al. (May 2008). "Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands".The Journal of Organic Chemistry.73 (9):3497–507.doi:10.1021/jo800028q.PMID 18363376.

nAChRsTooltip Nicotinic acetylcholine receptors

Agonists
(and PAMsTooltip positive allosteric modulators)

Antagonists
(and NAMsTooltip negative allosteric modulators)

See also: Receptor/signaling modulators; Muscarinic acetylcholine receptor modulators; Acetylcholine metabolism/transport modulators

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