Protein-coding gene in the species Homo sapiens
Ras homolog gene family, member B , also known asRHOB , is aprotein which in humans is encoded by theRHOB gene .[ 5] [ 6]
RHOB is a member of theRho GTP-binding protein family.[ 7]
RHOB has been shown tointeract withCIT ,[ 8] ARHGEF3 ,[ 9] ARHGDIG [ 10] RHPN2 .[ 11]
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Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG" .The Journal of Biological Chemistry .271 (48):30366– 74.doi :10.1074/jbc.271.48.30366 PMID 8939998 . ^ Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C, Pirson I (December 2002)."Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP" (PDF) .European Journal of Biochemistry .269 (24):6241– 9.doi :10.1046/j.1432-1033.2002.03343.x .PMID 12473120 .S2CID 23901713 . Bravo-Nuevo A, Sugimoto H, Iyer S, Fallon Z, Lucas JM, Kazerounian S, Prendergast GC, Kalluri R, Shapiro NI, Benjamin LE (January 2011)."RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice" .The American Journal of Pathology .178 (1):245– 52.doi :10.1016/j.ajpath.2010.11.040 .PMC 3069827 PMID 21224061 . 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Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG" .The Journal of Biological Chemistry .271 (48):30366– 74.doi :10.1074/jbc.271.48.30366 PMID 8939998 . Mellor H, Flynn P, Nobes CD, Hall A, Parker PJ (February 1998)."PRK1 is targeted to endosomes by the small GTPase, RhoB" .The Journal of Biological Chemistry .273 (9):4811– 4.doi :10.1074/jbc.273.9.4811 PMID 9478917 . Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998)."Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" .DNA Research .5 (3):169– 76.doi :10.1093/dnares/5.3.169 PMID 9734811 . Liu JP, Jessell TM (December 1998). "A role for rhoB in the delamination of neural crest cells from the dorsal neural tube".Development .125 (24):5055– 67.doi :10.1242/dev.125.24.5055 .PMID 9811589 . 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