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RG-7351

From Wikipedia, the free encyclopedia
TAAR1 agonist

Pharmaceutical compound
RG-7351
Clinical data
Other namesRG7351
Drug classTrace amine-associated receptor 1 (TAAR1)partial agonist

RG-7351 is atrace amine-associated receptor 1 (TAAR1)partial agonist that is or was under development for the treatment ofmajor depressive disorder.[1][2][3][4] It reachedphase 1clinical trials for this indication in 2010.[1][2][4] However, as of November 2023, no further recent development has been reported since July 2016.[1] The drug was developed byHoffmann-La Roche.[1][2][4]

See also

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References

[edit]
  1. ^abcd"RG 7351".AdisInsight. Springer Nature Switzerland AG. 5 November 2023. Retrieved20 October 2024.
  2. ^abc"Delving into the Latest Updates on RG-7351 with Synapse".Synapse. 19 September 2024. Retrieved20 October 2024.
  3. ^Liu JF, Li JX (2018)."TAAR1 in Addiction: Looking Beyond the Tip of the Iceberg".Frontiers in Pharmacology.9: 279.doi:10.3389/fphar.2018.00279.PMC 5881156.PMID 29636691.
  4. ^abcWu R, Liu J, Li JX (2022). "Trace amine-associated receptor 1 and drug abuse".Behavioral Pharmacology of Drug Abuse: Current Status. Adv Pharmacol. Vol. 93. pp. 373–401.doi:10.1016/bs.apha.2021.10.005.ISBN 978-0-323-91526-7.PMC 9826737.PMID 35341572.
TAAR1Tooltip Trace amine-associated receptor 1
Agonists
Endogenous
Exogenous
Antagonists
Inverse agonists
TAAR5Tooltip Trace amine-associated receptor 5
Agonists
Inverse agonists
Notes: (1) TAAR1 activity of ligands varies significantly between species. Some agents that are TAAR1 ligands in some species are not in other species. This navbox includes all TAAR1 ligands regardless of species. (2) See the individual pages for references, as well as theList of trace amines,TAAR, andTAAR1 pages.See also:Receptor/signaling modulators


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