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Pyrrolobenzodiazepine

From Wikipedia, the free encyclopedia
Medical compound
Anthramycin contains pyrrolobenzodiazepine core

Pyrrolobenzodiazepines, (PBD) are a class of compound that may haveantibiotic or anti-tumor properties.[1]

Some dimeric pyrrolobenzodiazepines are used as the cytotoxic drug payloads inantibody-drug conjugates, for example inloncastuximab tesirine.

History

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Anthramycin, the first PBD monomer, was first synthesized in the 1960s.[2]

References

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  1. ^Hartley JA (June 2011). "The development of pyrrolobenzodiazepines as antitumour agents".Expert Opinion on Investigational Drugs.20 (6):733–44.doi:10.1517/13543784.2011.573477.PMID 21457108.S2CID 26275418.
  2. ^Mantaj, Julia; Jackson, Paul J. M.; Rahman, Khondaker M.; Thurston, David E. (2017)."From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody–Drug Conjugates (ADCs)".Angewandte Chemie International Edition.56 (2):462–488.doi:10.1002/anie.201510610.PMC 5215561.PMID 27862776.
1,4-Benzodiazepines
1,5-Benzodiazepines
2,3-Benzodiazepines*
Triazolobenzodiazepines
Imidazobenzodiazepines
Oxazolobenzodiazepines
Thienodiazepines
Thienotriazolodiazepines
Thienobenzodiazepines*
Pyridodiazepines
Pyridotriazolodiazepines
Pyrazolodiazepines
Pyrrolodiazepines
Tetrahydroisoquinobenzodiazepines
Pyrrolobenzodiazepines*
Benzodiazepine prodrugs
* atypical activity profile (notGABAA receptor ligands)
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Depressants
Hallucinogens
Entactogens
Psychiatric drugs
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