Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Pyrrolidinylmethylindole

From Wikipedia, the free encyclopedia
Class of chemical compounds

Pyrrolidinylmethylindoles, or3-(pyrrolidin-2-ylmethyl)-1H-indoles, also known asα,N-trimethylenetryptamines, are a group ofcyclized tryptamines in which theamine has beencyclized with theα position of theethylside chain via apropyl group to form apyrrolidinering. They include thepsychedelic and related compoundsMPMI,4-HO-MPMI (lucigenol),5F-MPMI, and5-MeO-MPMI and thetriptans and related compoundseletriptan andCP-135807. Pyrrolidinylmethylindoles are known to act asserotonin receptor agonists, including of theserotonin5-HT1 and/or5-HT2 receptors.[1][2][3][4][5]

Chemical structures of selected pyrrolidinylmethylindoles


See also

[edit]

References

[edit]
  1. ^Macor JE, Blake J, Fox CB, Johnson C,Koe BK, Lebel LA, Morrone JM, Ryan K, Schmidt AW, Schulz DW, et al. (1992). "Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin".Journal of Medicinal Chemistry.35 (23):4503–5.doi:10.1021/jm00101a032.PMID 1447752.
  2. ^Gerasimov M, Marona-Lewicka D, Kurrasch-Orbaugh DM, Qandil AM, Nichols DE (1999). "Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain".Journal of Medicinal Chemistry.42 (20):4257–4263.CiteSeerX 10.1.1.690.4941.doi:10.1021/jm990325u.PMID 10514296.
  3. ^WO 2022/256554, Wallach J, Dybek M, "Fluorinated Tryptamine Compounds, Analogues Thereof, and Methods Using Same", published 8 December 2022, assigned to University of the Sciences in Philadelphia.  Retrieved 2025-05-14
  4. ^Mansbach RS, Rovetti CC, Macor JE (December 1996). "CP-135,807, a selective 5-HT1D agonist: effects in drug discrimination and punishment procedures in the pigeon".Psychopharmacology (Berl).128 (3):313–319.doi:10.1007/s002130050139.PMID 8972551.
  5. ^McCormack PL, Keating GM (2006). "Eletriptan: a review of its use in the acute treatment of migraine".Drugs.66 (8):1129–1149.doi:10.2165/00003495-200666080-00010.PMID 16789799.


Tryptamines
No ring subs.
4-Hydroxytryptamines
5-Hydroxytryptamines
5-Methoxytryptamines
Other ring subs.
α-Alkyltryptamines
Others
Cyclized
Bioisosteres
Phenethylamines
Scalines
2C-x
3C-x
DOx
4C-x
Ψ-PEA
MDxx
FLY
25x-NB (NBOMes)
Others
Cyclized
Lysergamides
  • Bioisosteres:JRT
Others
Natural sources
5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
5-HT2
5-HT2A
5-HT2B
5-HT2C
5-HT37
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7
Tryptamines
4-Hydroxytryptamines
andesters/ethers
5-Hydroxy- and
5-methoxytryptamines
N-Acetyltryptamines
α-Alkyltryptamines
Cyclized tryptamines
Isotryptamines
Related compounds


Stub icon

This article about anorganic compound is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Pyrrolidinylmethylindole&oldid=1321052995"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp