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Pukateine

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
Pukateine
Clinical data
Other names(R)-11-hydroxy-1,2-methylenedioxyaporphine
ATC code
  • none
Identifiers
  • (7aR)-7-methyl-6,7,7a,8-tetrahydro-5H-benzo[g][1,3]benzodioxolo[6,5,4-de]quinolin-12-ol
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC18H17NO3
Molar mass295.338 g·mol−1
3D model (JSmol)
  • CN1CCC2=CC3=C(C4=C2[C@H]1CC5=C4C(=CC=C5)O)OCO3
  • InChI=1S/C18H17NO3/c1-19-6-5-11-8-14-18(22-9-21-14)17-15(11)12(19)7-10-3-2-4-13(20)16(10)17/h2-4,8,12,20H,5-7,9H2,1H3/t12-/m1/s1 ☒N
  • Key:IKMXUUHNYQWZBC-GFCCVEGCSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Pukateine is analkaloid found in the bark of theNew Zealand treeLaurelia novae-zelandiae ("Pukatea"), as well as some South American plants.[1] An extract from pukatea is used in traditionalMāoriherbal medicine as ananalgesic.[2][3]

Bernard Cracroft Aston studied the physical and chemical characteristics of the compound, and presented a paper with his findings to theRoyal Society of New Zealand on 11 May 1909.[4]

See also

[edit]

References

[edit]
  1. ^Quiroz-Carreño S, Pastene-Navarrete E, Espinoza-Pinochet C, Muñoz-Núñez E, Devotto-Moreno L, Céspedes-Acuña CL, Alarcón-Enos J (November 2020)."Assessment of Insecticidal Activity of Benzylisoquinoline Alkaloids from Chilean Rhamnaceae Plants against Fruit-Fly Drosophila melanogaster and the Lepidopteran Crop Pest Cydia pomonella".Molecules.25 (21). Basel, Switzerland: 5094.doi:10.3390/molecules25215094.PMC 7663414.PMID 33153001.
  2. ^Dajas-Bailador FA, Asencio M, Bonilla C, Scorza MC, Echeverry C, Reyes-Parada M, Silveira R, Protais P, Russell G, Cassels BK, Dajas F (March 1999). "Dopaminergic pharmacology and antioxidant properties of pukateine, a natural product lead for the design of agents increasing dopamine neurotransmission".General Pharmacology.32 (3):373–9.doi:10.1016/s0306-3623(98)00210-9.PMID 10211594.
  3. ^Valiente M, D'Ocon P, Noguera MA, Cassels BK, Lugnier C, Ivorra MD (July 2004). "Vascular activity of (-)-anonaine, (-)-roemerine and (-)-pukateine, three natural 6a(R)-1,2-methylenedioxyaporphines with different affinities for alpha1-adrenoceptor subtypes".Planta Medica.70 (7):603–9.doi:10.1055/s-2004-827181.PMID 15254852.S2CID 260249660.
  4. ^Aston BC (1909)."The Alkaloids of the Pukatea".Transactions of the Royal Society of New Zealand.42. RetrievedOctober 20, 2015.
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