Psyllium (/ˈsɪliəm/), orIsabgol[1] orispaghula (/ˌɪspəˈɡuːlə/), is the common name used for several members of the plant genusPlantago whose seeds are used commercially for the production ofmucilage. Psyllium is mainly used as adietary fiber to relieve symptoms of bothconstipation and milddiarrhea, and occasionally as afood thickener.[2] Allergy to psyllium is common in workers frequently exposed to the substance.
It is generally safe and moderately effective as alaxative.[3][4] Use of psyllium in the diet for three weeks or longer may lowerblood cholesterol levels in people with elevated cholesterol,[5][6] and may lowerblood glucose levels in people withtype 2 diabetes.[7] Use of psyllium for a month or longer may produce a small reduction insystolic blood pressure.[8]
The plants from which the seeds are extracted tolerate damp and cool climates, and are mainly cultivated in northernIndia.
Psyllium is produced mainly for itsmucilage content. The termmucilage describes a group of clear, colorless, gelling agents derived from plants. The mucilage obtained from psyllium comes from the seed coat. Mucilage is obtained by mechanical milling (i.e. grinding) of the outer layer of the seed. Mucilage yield amounts to about 25% (by weight) of the total seed yield. Plantago-seed mucilage is often referred to ashusk, or psyllium husk. The milled seed mucilage is a white fibrous material that ishydrophilic, meaning that its molecular structure causes it to attract and bind to water.[3][9]
Psyllium has been used as athickener in ice cream and other frozen desserts. A 1.5% weight/volume ratio of psyllium mucilage exhibits binding properties that are superior to a 10% weight/volume ratio of starch mucilage.[10] Theviscosity of psyllium mucilage dispersions is relatively unaffected between temperatures of 20 and 50 °C (68 and 122 °F), bypH from 2 to 10, and bysalt (sodium chloride) concentrations up to 0.15 M.[10]Psyllium seed husks can also be used to improve texture ingluten-free baked goods, to bindmeatballs, and to thicken sauces.[11] Some people use them to manage symptoms ofirritable bowel syndrome.
Dietary supplements containing psyllium are sold mainly to aidweight loss, although there is littlescientific evidence for such effects.[12]
A 2023 review concluded that psyllium supplementation for 12 weeks by people who were overweight or obese produced a minor amount of weight loss, although the studies assessed had only moderate to low evidence quality.[9]
Psyllium is mainly used as aviscous,soluble dietary fiber that is not absorbed by thesmall intestine.[13] The mechanical action of psyllium mucilage is to absorb excess water while stimulating normal bowel elimination.[4] Although its main use has been as alaxative, it is more accurately regarded as a dietary fiber to reduce the symptoms of both constipation and milddiarrhea.[13][4] The laxative properties of psyllium are attributed to the fiber: it absorbs water and subsequently softens the stool.[13][3] It increasesflatulence (gas) to some degree.[14] Psyllium reduces straining during defecation by increasing the bulk of stools, thereby facilitating the transit of stools in the colon.[3] When used to treat constipation, psyllium is taken in doses of 3.5–11 grams per day twice daily.[4]
A 2021 review of over-the-counter treatments for constipation concluded that psyllium has modest effect in treating constipation and is generally safe and well-tolerated.[4] Psyllium may be less effective compared to other products, such aspolyethylene glycol,lactulose or fruits likeprunes.[4] Psyllium is more effective thandocusate.[4]
A 2022 review found that psyllium, in doses of 10 grams per day for at least 4 weeks, was more effective than osmotic or stimulant laxatives for increasing the number of bowel movements per week.[3]
In 1998, the U.S. Food and Drug Administration approved a health claim on food labels for dietary psyllium as asoluble fiber – if consumed regularly – that would reduce the risk ofheart disease by loweringblood cholesterol.[15] Clinical research demonstrated that seven grams or more per day of soluble fiber from psyllium seed husk would sufficiently lower totalcholesterol andlow-density lipoprotein cholesterol in people withhypercholesterolemia, two accepted biomarkers for risk ofcoronary heart disease.[16] The findings were later confirmed in ameta-analysis that incorporated more evidence.[17] To be eligible for the FDA-allowed health claim, one serving of a manufactured food or dietary supplement must contain at least 1.7 g of psyllium as soluble fiber.[15]Whole oats,barley and foods containingbeta-glucan soluble fiber were included as eligible sources for the label claim.[15]
In 2014, the U.S. Food and Drug Administration approved a qualified health claim for psyllium as a possible benefit for people withdiabetes, requiring FDA-approved wording on a product label: "Psyllium husk may reduce the risk of type 2 diabetes, although the FDA has concluded that there is very little scientific evidence for this claim."[18] A meta-analysis published after the FDA decision reported that psyllium provided before meals improved fasting blood glucose andglycated hemoglobin, but that the larger effect was seen in people diagnosed with and being treated for type 2 diabetes, and only a modest improvement for people classified as pre-diabetic.[7]
A 2019 meta-analysis found that use of supplemental psyllium for 8 weeks or longer reduced blood pressure by 2 mmHg in people withhypertension.[19]
Some psyllium supplements sold in the USA have been found to containlead,[20] in some cases exceeding levels requiring a warning label byProposition 65 of the U.S. state of California.[20] In 2013, in California, alegal settlement required the manufacturer of psyllium supplements to pay US$110,000 and agree to place warning labels on products exceeding acceptable lead levels.[21]
Psyllium is a commonly used fiber supplement for treating diarrhea and constipation in dogs.[22]
Psyllium fiber dietary supplements are used in veterinary medicine to treatsand impaction in horses to aid in elimination of sand from the horse's colon.[23]
Fiber generally has few side effects.[24]
Psyllium can causeallergic reactions, includinganaphylaxis.[28] Psyllium may act as a potent inhalant allergen capable of eliciting asthma symptoms.[29] Health care professionals at geriatric care hospitals, who are frequently exposed to psyllium in the laxatives administered to people, are commonlyIgE sensitized to psyllium (13.8%), and 8.6% have clinical allergy to psyllium.[30] In order to protect sensitized workers, psyllium has an extremely lowoccupational exposure limit of 150 ng/m3.[31]
The genusPlantago contains over 200 species.P. ovata andP. psyllium are produced commercially in several European countries, Russia and surrounding countries, andIndia. Plantago seed, known commercially as black, French, or Spanish psyllium, is obtained fromP. psyllium, also known asP. arenaria. Seed produced fromP. ovata is known in trading circles as white or blonde psyllium, Indian plantago, or isabgol. Isabgol is the common name in India forP. ovata. India dominates the world market in the production and export of psyllium.
Plantago ovata is an annual herb that grows to a height of 30–46 cm (12–18 in). Leaves are opposite, linear or linearlanceolate 1 cm × 19 cm (0.39 in × 7.48 in). The root system has a well-developed tap root with few fibrous secondary roots. A large number of flowering shoots arise from the base of the plant. Flowers are numerous, small, and white. Plants flower about 60 days after planting. The seeds are enclosed in capsules that open at maturity.
The fields are generally irrigated prior to seeding to achieve ideal soil moisture, to enhance seed soil contact, and to avoid burying the seed too deeply as a result of later irrigations or rainfall. Maximum germination occurs at a seeding depth of 6 mm (1/4 in). Emerging seedlings are frost sensitive; therefore, planting should be delayed until conditions are expected to remain frost free. Seed is broadcast at 5.5 to 8.25 kg/hectare (5 to 7.5 lb/acre) in India. In Arizonan trials, seeding rates of 22 to 27.5 kg/ha (20 to 25 lb/acre) resulted in stands of 1 plant/25mm (1 inch) in 15 cm (6 inch) rows produced excellent yields. Weed control is normally achieved by one or two hand weedings early in the growing season. Control of weeds by pre-plant irrigation that germinates weed seeds followed by shallowtillage may be effective on fields with minimal weed pressure. Psyllium is a poor competitor with most weed species.
Plantago wilt (Fusarium oxysporum) anddowny mildew (Peronospora alta) are the major diseases of Isabgol.White grubs andaphids are the major insect pests.
The flower spikes turn reddish brown at ripening, the lower leaves dry and the upper leaves yellow. The crop is harvested in the morning after the dew is gone to minimize shattering and field losses. In India, mature plants are cut 15 cm above the ground and then bound, left for a few days to dry, thrashed, andwinnowed.
Harvested seed must be dried to below 12% moisture to allow for cleaning, milling, and storage. Seed stored for future crops has shown a significant loss in viability after 2 years in storage.
The brand calledSat-Isabgol first went on sale in 1937, 10 years before British rule ended in India, and has been consumed by Indians since.[32]
Introduced in 1934 byG.D. Searle & Company, Metamucil was acquired byProcter & Gamble in 1985. The name is a combination of the Greek word for change (meta) and the class of fiber that it utilizes (mucilage). In its early years, Metamucil achieved sporadicdrug-store distribution as a "behind the counter" product – sold in pharmacies but not on the shelf, so that the pharmacist might counsel the purchaser on correct usage. Since 1974, the brand was also marketed to consumers by print and TV advertising and became available in food outlets. Flavored versions were added in 1979.
The brand is sold as powdereddrink mixes, capsules, gummies, and wafers in a variety of flavors. Metamucil contains psyllium seed husks as the active ingredient. It is manufactured in Phoenix, Arizona, by Procter & Gamble.[33] When first marketed to consumers in 1974, Metamucil was marketed as a laxative. The advertising slogan at that time was "If not nature, then Metamucil". Procter & Gamble sought to make Metamucil a household name by advertising in magazines and on television, using the claim "All fiber is not created equal".[34]
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