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Psychotridine

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
Psychotridine
Clinical data
ATC code
  • none
Identifiers
  • 3-methyl-5,8b-bis[3-methyl-5-(3-methyl-1,2,3a,4-tetrahydropyrrolo[2,3-b]indol-8b-yl)-1,2,3a,4-tetrahydropyrrolo[2,3-b]indol-8b-yl]-1,2,3a,4-tetrahydropyrrolo[2,3-b]indole
CAS Number
PubChemCID
ChemSpider
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC55H62N10
Molar mass863.171 g·mol−1
3D model (JSmol)
  • CN1CCC2(C1NC1=CC=CC=C21)C1=CC=CC2=C1NC1N(C)CCC21C1=CC=CC2=C1NC1N(C)CCC21C12CCN(C)C1NC1=C2C=CC=C1C12CCN(C)C1NC1=CC=CC=C21

Psychotridine is analkaloid found in some species of the genusPsychotria, namelyPsychotria colorata,[1] but alsoPsychotria forsteriana,[2]Psychotria lyciiflora,[3]Psychotria oleoides,[3] andPsychotria beccarioides.[4] Psychotridine hasanalgesic effects and dose-dependently inhibitsdizocilpine binding to cortical membranesin vitro, suggesting that it acts as anon-competitiveNMDA receptor antagonist.[1]

See also

[edit]

References

[edit]
  1. ^abAmador TA, Verotta L, Nunes DS, Elisabetsky E (May 2001). "Involvement of NMDA receptors in the analgesic properties of psychotridine".Phytomedicine.8 (3):202–206.doi:10.1078/0944-7113-00025.PMID 11417913.
  2. ^Beretz A, Roth-Georger A, Corre G, Kuballa B, Anton R, Cazenave JP (August 1985). "Polyindolinic Alkaloids from Psychotria forsteriana. Potent Inhibitors of the Aggregation of Human Platelets".Planta Medica.51 (4):300–303.doi:10.1055/s-2007-969496.PMID 17340518.S2CID 12146923.
  3. ^abJannic V, Guéritte F, Laprévote O, Serani L, Martin MT, Sévenet T, Potier P (June 1999). "Pyrrolidinoindoline alkaloids from Psychotria oleoides and Psychotria lyciiflora".Journal of Natural Products.62 (6):838–843.doi:10.1021/np9805387.PMID 10395499.
  4. ^Hart N, Johns S, Lamberton J, Summons R (1974). "Psychotridine, a C55H62N10 alkaloid from Psychotria beccarioides (Rubiaceae)".Australian Journal of Chemistry.27 (3):639–646.doi:10.1071/ch9740639.
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AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor


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