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Pseudomonas exotoxin

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From Wikipedia, the free encyclopedia

Exotoxin produced by Pseudomonas aeruginosa

Exotoxin A

Exotoxin A dimer,Pseudomonas aeruginosa

Identifiers

Organism

Pseudomonas aeruginosa

Symbol

eta

Other data

Search for
Structures	Swiss-model
Domains	InterPro

For the Streptococcal superantigen SpeA, also referred to asexotoxin A, seeErythrogenic toxin.

ThePseudomonas exotoxin (orexotoxin A) is anexotoxin produced byPseudomonas aeruginosa.^[1]Vibrio cholerae produces a similar protein called theCholix toxin (Q5EK40).^[2]

It inhibitselongation factor-2. It does so byADP-ribosylation of EF2 usingNAD+. This then causes the elongation of polypeptides to cease. This mechanism is similar to that ofdiphtheria toxin.^[3]

It has been investigated as a treatment forhepatitis B^[4] and cancer.^[5]

References

[edit]

^Yates SP, Taylor PL, Jørgensen R, Ferraris D, Zhang J, Andersen GR, Merrill AR (February 2005)."Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa".The Biochemical Journal.385 (Pt 3):667–75.doi:10.1042/BJ20041480.PMC 1134741.PMID 15458385.
^Jørgensen R, Purdy AE, Fieldhouse RJ, Kimber MS, Bartlett DH, Merrill AR (April 2008)."Cholix toxin, a novel ADP-ribosylating factor from Vibrio cholerae".The Journal of Biological Chemistry.283 (16):10671–8.doi:10.1074/jbc.M710008200.PMID 18276581.
^Yates SP, Merrill AR (May 2004)."Elucidation of eukaryotic elongation factor-2 contact sites within the catalytic domain of Pseudomonas aeruginosa exotoxin A".The Biochemical Journal.379 (Pt 3):563–72.doi:10.1042/BJ20031731.PMC 1224111.PMID 14733615.
^Hafkemeyer P, Brinkmann U, Brinkmann E, Pastan I, Blum HE, Baumert TF (May 2008)."Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells".World Journal of Gastroenterology.14 (18):2810–7.doi:10.3748/wjg.14.2810.PMC 2710720.PMID 18473403.
^Stuckey DW, Hingtgen SD, Karakas N, Rich BE, Shah K (February 2015)."Engineering toxin-resistant therapeutic stem cells to treat brain tumors".Stem Cells.33 (2):589–600.doi:10.1002/stem.1874.PMC 4305025.PMID 25346520.

External links

[edit]

Media related toPseudomonas exotoxin at Wikimedia Commons
P11439 (eta) in InterPro domain view

Toxins

Clostridium:	tetani Tetanospasmin Tetanolysin perfringens Alpha toxin Enterotoxin difficile A B botulinum Botox
Other:	Anthrax toxin Listeriolysin O

Cocci

Streptolysin Leukocidin Panton–Valentine leukocidin
Staphylococcus	Staphylococcus aureus alpha/beta/delta Exfoliatin Toxic shock syndrome toxin Staphylococcal Enterotoxin B (SEB)

Lipopolysaccharide
- Lipid A
Bacillus thuringiensis delta endotoxin
- Cry1Ac
- Cry3Bb1
OtherB. thuringiensis toxins
- Cry6Aa
- Cry34Ab1

Virulence
factor

Mycotoxins

Plant toxins

Invertebrate
toxins

Scorpion:	Androctonus australis hector insect toxin Charybdotoxin Maurotoxin Agitoxin Margatoxin Slotoxin Scyllatoxin Hefutoxin HgeTx1 HsTx1 Kaliotoxin Lq2 Birtoxin Bestoxin BmKAEP Phaiodotoxin Imperatoxin Pi3
Spider:	Latrotoxin Alpha-latrotoxin CSTX Cupiennins PhTx3 Stromatoxin Vanillotoxin Huwentoxin
Mollusca:	Conotoxin Eledoisin Onchidal Saxitoxin Tetrodotoxin

Vertebrate
toxins

Fish:	Ciguatoxin Tetrodotoxin
Amphibian:	(+)-Allopumiliotoxin 267A Batrachotoxin Bufotoxins Arenobufagin Bufotalin Bufotenin Cinobufagin Marinobufagin Epibatidine Histrionicotoxin Pumiliotoxin 251D Samandarin Samandaridine Tarichatoxin Zetekitoxin AB
Reptile/ Snake venom:	Bungarotoxin α-Bungarotoxin β-Bungarotoxin Calciseptine Taicatoxin Calcicludine Cardiotoxin III

note: some toxins are produced by lower species and pass through intermediate species

Category

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