The intergenic region containingPseudomon-1 RNAs were also detected later by an independent study based on deep sequencing and called SPA0122[2] The genes surrounding this region suggest a similarity toSpot 42 RNA,[2] but thePseudomonas RNA functions to regulate the AlgC enzyme[3] Based on this information, the new nameErsA for the RNA was adopted.[3] Negatively regulates major porinoprD expression responsible for uptake ofcarbapenem antibiotics, by base pairing withoprD5′UTR (leading to increased bacterial resistance tomeropenem).[4] ErsA positively regulates amrZ mRNA and contributes to biofilm formation and motility.[5]
^abFerrara S, Carloni S, Fulco R, Falcone M, Macchi R, Bertoni G (January 2015). "Post-transcriptional regulation of the virulence-associated enzyme AlgC by the σ(22) -dependent small RNA ErsA of Pseudomonas aeruginosa".Environmental Microbiology.17 (1):199–214.Bibcode:2015EnvMi..17..199F.doi:10.1111/1462-2920.12590.PMID25186153.
