| Acid-activated urea/amide channel | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Urea channel hexamer (side view) from Helicobacter pylori | |||||||||
| Identifiers | |||||||||
| Symbol | UAC | ||||||||
| Pfam | PF02293 | ||||||||
| TCDB | 1.A.29 | ||||||||
| OPM superfamily | 299 | ||||||||
| OPM protein | 3ux4 | ||||||||
| |||||||||
Theproton-gated urea channel is an inner-membraneprotein essential for the survival toHelicobacter pylori. It enables the rapid influx ofurea into the bacterium. It is closed at pH 7.0 and fully open at pH 5.0.Urease activity buffers theperiplasm to pH 6.1. Usingmultiwavelength anomalous dispersion (MAD), its structure, a compacthexameric ring about 95 Å in diameter and 45 A ̊ in height, was determined. The centre is filled with alipid plug that forms an asymmetricbilayer. Amino residues that can be protonated in the periplasmic domain are important for proton sensing or gating.[1]
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