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Proterguride

From Wikipedia, the free encyclopedia

Pharmaceutical compound
Proterguride
Clinical data
Other namesVUFB-13416; VUFB13416; ZK-39437; ZK39437; 6-Propylterguride; 6-Propyl-9,10-dihydrolisuride;N,N-Diethyl-N'-(6-propylergolin-8α-yl)urea
Drug classDopamine agonist;Prolactin inhibitor;Antiparkinsonian agent
ATC code
  • None
Identifiers
  • 3-[(6aR,9S,10aR)-7-propyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinolin-9-yl]-1,1-diethylurea
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC22H32N4O
Molar mass368.525 g·mol−1
3D model (JSmol)
  • CCCN1C[C@H](C[C@H]2[C@H]1CC3=CNC4=CC=CC2=C34)NC(=O)N(CC)CC
  • InChI=1S/C22H32N4O/c1-4-10-26-14-16(24-22(27)25(5-2)6-3)12-18-17-8-7-9-19-21(17)15(13-23-19)11-20(18)26/h7-9,13,16,18,20,23H,4-6,10-12,14H2,1-3H3,(H,24,27)/t16-,18+,20+/m0/s1
  • Key:FCRJELOYDVBTGW-ILZDJORESA-N

Proterguride (INNTooltip International Nonproprietary Name; developmental code namesVUFB-13416,ZK-39437), also known as6-propylterguride or6-propyl-9,10-dihydrolisuride, is adopamine agonist of theergoline family described as aprolactin inhibitor andantiparkinsonian agent which was never marketed.[1][2][3][4][5] It is closelystructurally related to certain other ergolines liketerguride andlisuride.[1][4] Besidesdopamine receptors, the drug also interacts withserotonin,adrenergic, andhistamine receptors.[5] Proterguride was first described in the literature by at least 1981.[1]

References

[edit]
  1. ^abcElks J (14 November 2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer.ISBN 978-1-4757-2085-3. Retrieved30 June 2025.
  2. ^Milne G (8 May 2018).Drugs: Synonyms and Properties. Routledge.ISBN 978-1-351-78990-5. Retrieved30 June 2025.
  3. ^Negwer M (2001).Organic-chemical Drugs and Their Synonyms: An International Survey. Wiley-VCH.ISBN 978-3-527-30247-5. Retrieved30 June 2025.
  4. ^abIta K (June 2017). "Recent trends in the transdermal delivery of therapeutic agents used for the management of neurodegenerative diseases".Journal of Drug Targeting.25 (5):406–419.doi:10.1080/1061186X.2016.1245310.PMID 27701893.Proterguride (N6-propylterguride or N6-propyldihydrolisuride) is an ergoline derivative with potent dopaminergic activity [124, 125]. It has been reported that strong dopaminergic activity can be achieved at plasma concentrations below 50 pg/mL [125]. Physiologic dopamine receptor stimulation in the human striatum can be simulated by continuous administration of proterguride (PT) [125].
  5. ^abSchurad B, Horowski R, Jähnichen S, Görnemann T, Tack J, Pertz HH (April 2006). "Proterguride, a highly potent dopamine receptor agonist promising for transdermal administration in Parkinson's disease: interactions with alpha(1)-, 5-HT(2)- and H(1)-receptors".Life Sciences.78 (20):2358–2364.doi:10.1016/j.lfs.2005.09.046.PMID 16310806.


D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists
α1
Agonists
Antagonists
α2
Agonists
Antagonists
β
Agonists
Antagonists
5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
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5-HT2A
5-HT2B
5-HT2C
5-HT3–7
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7
Ergolines
(incl.lysergines)
Clavines
(6,8-dimethylergolines)
Lysergamides
(lysergic acid amides)
Ergopeptines
(peptide ergolines)
Partial ergolines
Related compounds
Natural sources


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