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Protein kinase, AMP-activated, alpha 1

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

PRKAA1

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
4RED,4RER,4REW,5EZV

Identifiers

Aliases

PRKAA1, AMPK, AMPKa1, Protein kinase, AMP-activated, alpha 1, protein kinase AMP-activated catalytic subunit alpha 1

External IDs

OMIM:602739;MGI:2145955;HomoloGene:49590;GeneCards:PRKAA1;OMA:PRKAA1 - orthologs

EC number

2.7.11.26

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	n/a	Start	40,759,379bp^[1]
Band	n/a	End	40,798,374bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15\|15 A1	Start	5,173,343bp^[2]
Band	15\|15 A1	End	5,211,380bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

sperm

rectum

gallbladder

gastric mucosa

stromal cell of endometrium

epithelium of colon

tibial arteries

body of pancreas

Descending thoracic aorta

Top expressed in

granulocyte

islet of Langerhans

epithelium of small intestine

mammillary body

white adipose tissue

hand

ventromedial nucleus

medial vestibular nucleus

lateral hypothalamus

ventral tegmental area

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity nucleotide binding protein kinase activity cAMP-dependent protein kinase activity [acetyl-CoA carboxylase kinase activity] AMP-activated protein kinase activity histone serine kinase activity chromatin binding metal ion binding kinase activity protein serine/threonine kinase activity tau-protein kinase activity protein C-terminus binding protein binding [hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity] ATP binding tau protein binding
Cellular component	nucleotide-activated protein kinase complex apical plasma membrane nucleoplasm nucleus cytoplasm cytosol nuclear speck intracellular anatomical structure axon dendrite protein-containing complex soma
Biological process	cellular response to organonitrogen compound steroid metabolic process cellular response to glucose starvation sterol biosynthetic process lipid biosynthetic process regulation of transcription, DNA-templated response to hypoxia cellular response to ethanol glucose homeostasis positive regulation of skeletal muscle tissue development protein heterooligomerization rhythmic process phosphorylation lipid metabolism regulation of vesicle-mediated transport negative regulation of apoptotic process cholesterol metabolic process Wnt signaling pathway response to activity fatty acid metabolic process transcription, DNA-templated cellular response to prostaglandin E stimulus autophagy protein phosphorylation negative regulation of TOR signaling cold acclimation positive regulation of gene expression response to camptothecin fatty acid biosynthetic process fatty acid homeostasis regulation of circadian rhythm fatty acid oxidation regulation of peptidyl-serine phosphorylation cellular response to nutrient levels positive regulation of cell population proliferation negative regulation of glucosylceramide biosynthetic process glucose metabolic process positive regulation of cholesterol biosynthetic process response to caffeine cholesterol biosynthetic process negative regulation of lipid catabolic process response to gamma radiation macroautophagy response to UV positive regulation of glycolytic process response to hydrogen peroxide cellular response to hypoxia signal transduction cellular response to hydrogen peroxide steroid biosynthetic process regulation of signal transduction by p53 class mediator positive regulation of autophagy CAMKK-AMPK signaling cascade regulation of macroautophagy chromatin organization positive regulation of mitochondrial transcription positive regulation of protein targeting to mitochondrion negative regulation of gene expression cellular response to oxidative stress intracellular signal transduction negative regulation of insulin receptor signaling pathway motor behavior regulation of stress granule assembly neuron cellular homeostasis regulation of microtubule cytoskeleton organization cellular response to calcium ion cellular response to glucose stimulus energy homeostasis positive regulation of protein localization negative regulation of tubulin deacetylation positive regulation of peptidyl-lysine acetylation
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


5562


105787

Ensembl


ENSG00000132356


ENSMUSG00000050697

UniProt


Q13131


Q5EG47

RefSeq (mRNA)


NM_006251 NM_206907


NM_001013367 NM_001355640

RefSeq (protein)

NP_006242 NP_996790 NP_001341957 NP_001341958 NP_001341963
NP_001341964 NP_001341965 NP_001341966


NP_001013385 NP_001342569

Location (UCSC)

Chr 5: 40.76 – 40.8 Mb

Chr 15: 5.17 – 5.21 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

5'-AMP-activated protein kinase catalytic subunit alpha-1 is anenzyme that in humans is encoded by thePRKAA1gene.^[5]^[6]

The protein encoded by this gene belongs to theserine/threonine protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellularAMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes throughphosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways.Alternatively spliced transcript variants encoding distinctisoforms have been observed.^[6] A recent study proposes a role in the metastatic cascade and phenotype determination of pancreatic cancer.^[7]

Interactions

[edit]

Protein kinase, AMP-activated, alpha 1 has been shown tointeract withTSC2.^[8]^[9]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000132356 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000050697 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, et al. (Feb 1996)."Mammalian AMP-activated protein kinase subfamily".Journal of Biological Chemistry.271 (2):611–614.doi:10.1074/jbc.271.2.611.PMID 8557660.
^^a ^b"Entrez Gene: PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit".
^Schneider C, Hilbert J, Genevaux F, Hofer S, Krauss L, Schicktanz F, et al. (2024-06-17)."A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction".Advanced Science.11 (31) 2307695. Weinheim, Baden-wurttemberg, Germany.Bibcode:2024AdvSc..1107695S.doi:10.1002/advs.202307695.ISSN 2198-3844.PMC 11336956.PMID 38885414.
^Inoki K, Zhu T, Guan KL (Nov 2003)."TSC2 mediates cellular energy response to control cell growth and survival".Cell.115 (5). United States:577–590.doi:10.1016/S0092-8674(03)00929-2.ISSN 0092-8674.PMID 14651849.S2CID 18173817.
^Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, et al. (Jul 2004)."The LKB1 tumor suppressor negatively regulates mTOR signaling".Cancer Cell.6 (1). United States:91–99.doi:10.1016/j.ccr.2004.06.007.ISSN 1535-6108.PMID 15261145.

External links

[edit]

PDBe-KB provides an overview of all the structure information available in the PDB for Human 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)

v t e PDB gallery
2h6d: Protein Kinase Domain of the Human 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK alpha-2 chain)

Kinases:Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1
Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1 PDK2 PDK3 PDK4
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)	BCKDK BCKDHA BCKDHB
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2 IDH3A IDH3B IDH3G
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4
Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase Aurora A kinase Aurora B kinase Aurora C kinase
Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK STK10
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-
IκB kinase (EC 2.7.11.10)	CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP
cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A PRKACG PRKACB PRKACA PRKY
cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G PRKG1
Protein kinase C (EC 2.7.11.13)	Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3
Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase
Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2
G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4 GRK5 GRK6
Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2 CAMK1 CAMK1A CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1
Myosin light-chain kinase (EC 2.7.11.18)	MYLK MYLK2 MYLK3 MYLK4
Phosphorylase kinase (EC 2.7.11.19)	PHKA1 PHKA2 PHKB PHKG1 PHKG2
Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K STK19
Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4
Cyclin-dependent kinase (EC 2.7.11.22)	CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDK12 CDC2L5 PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1
Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14
MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14
Tau-protein kinase (EC 2.7.11.26)	TPK1 TTK GSK-3
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-
Tropomyosin kinase (EC 2.7.11.28)	-
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-
Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

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