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Prosultiamine

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Prosultiamine
Skeletal formula of prosultiamine
Ball-and-stick model of the prosultiamine molecule
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
  • None
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(1E)-4-hydroxy-1-methyl-2-(propyldisulfanyl)but-1-en-1-yl]formamide
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
ECHA InfoCard100.000.397Edit this at Wikidata
Chemical and physical data
FormulaC15H24N4O2S2
Molar mass356.50 g·mol−1
3D model (JSmol)
  • O=CN(\C(=C(\SSCCC)CCO)C)Cc1cnc(nc1N)C

Prosultiamine (INN; also known asthiamine propyl disulfide orTPD; brand nameJubedel,) is adisulfidethiaminederivative discovered in garlic inJapan in the 1950s, and is similar toallithiamine. It was developed as a treatment forvitamin B1 deficiency.[1][2][3] It has improvedlipidsolubility relative to thiamine and is not rate-limited by dependency on intestinaltransporters for absorption, hence the reasoning for its development.[4][5]

Research

[edit]

It has been studied as a potential treatment for infection withhuman T-lymphotropic virus (HTLV), since it has been shown to reduce viral load and symptoms.[6]

See also

[edit]

References

[edit]
  1. ^Swiss Pharmaceutical Society (2000).Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers.ISBN 3-88763-075-0.
  2. ^Triggle DJ (1997).Dictionary of pharmacological agents. London: Chapman & Hall.ISBN 0-412-46630-9.
  3. ^Fujiwara M, Watanabe H, Matsui K (1954). ""allithiamine" A Newly Found Derivative of Vitamin B1".The Journal of Biochemistry.41:29–39.doi:10.1093/oxfordjournals.jbchem.a126421.
  4. ^Thomson AD, Frank O, Baker H, Leevy CM (April 1971). "Thiamine propyl disulfide: absorption and utilization".Annals of Internal Medicine.74 (4):529–534.doi:10.7326/0003-4819-74-4-529.PMID 5551161.
  5. ^Baker H, Frank O (August 1976)."Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines".Journal of Nutritional Science and Vitaminology. 22 SUPPL:63–68.doi:10.3177/jnsv.22.supplement_63.PMID 978282.
  6. ^"Nervous System Disease: A New Outlet for an Old Drug?".Science Daily. 15 August 2013.
Fat
soluble
A
D
E
K
Water
soluble
B
C
Combinations
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