| prostaglandin-E synthase | |||||||||
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| Identifiers | |||||||||
| EC no. | 5.3.99.3 | ||||||||
| CAS no. | 52227-79-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDBPDBePDBsum | ||||||||
| Gene Ontology | AmiGO /QuickGO | ||||||||
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Prostaglandin E synthase (EC5.3.99.3, orPGE synthase) is anenzyme involved ineicosanoid andglutathione metabolism, a member ofMAPEG family. It generatesprostaglandin E (PGE) fromprostaglandin H2.[2][3]
The synthase generating PGE2 is a membrane-associated protein.
Humans express three prostaglandin-E synthaseisozymes, each encoded by a separate gene:
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