| prostaglandin-D synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Human Prostaglandin-D2 synthase. PDB2wwp | |||||||||
| Identifiers | |||||||||
| EC no. | 5.3.99.2 | ||||||||
| CAS no. | 65802-85-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDBPDBePDBsum | ||||||||
| Gene Ontology | AmiGO /QuickGO | ||||||||
| |||||||||
Inenzymology, aprostaglandin-D synthase (EC5.3.99.2) is anenzyme thatcatalyzes thechemical reaction.
Thus, thesubstrate of this enzyme is(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate, whereas itsproduct is(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.
This enzyme belongs to the family ofisomerases, specifically a class of other intramolecularoxidoreductases. Thesystematic name of this enzyme class is(5,13) - (15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Delta-isomerase. Other names in everyday use includeprostaglandin-H2 Delta-isomerase,prostaglandin-R-prostaglandin D isomerase, andPGH-PGD isomerase. This enzyme participates inarachidonic acid metabolism.
In March 2012, American scientists reported a discovery that shows this enzyme triggers male baldness.[1] According to the discovery, levels of this enzyme are elevated in the cells of hair follicles located in bald patches on the scalp, but not in hairy areas. The research could lead to a cream to treat baldness.
As of late 2001, 7structures have been solved for this class of enzymes, withPDB accession codes1IYH,1IYI,1PD2,1V40,2CZT,2CZU, and2E4J.
Hematopoietic prostaglandin D synthase
