 Structure of proglumetacin | |||
Structures of the two metabolites | |||
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| Trade names | Afloxan, Protaxon, Proxil | ||
| Other names | 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoate | ||
| AHFS/Drugs.com | International Drug Names | ||
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| Pharmacokinetic data | |||
| Metabolism | Hepatic. Undergoesenterohepatic recirculation | ||
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| Chemical and physical data | |||
| Formula | C46H58ClN5O8 | ||
| Molar mass | 844.45 g·mol−1 | ||
| 3D model (JSmol) | |||
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Proglumetacin (usually supplied as themaleate salt) is anonsteroidal anti-inflammatory drug (NSAID). It is acodrug (that is, a mutualprodrug) ofindometacin andproglumide.[1] After oral intake, it is absorbed and metabolized to indometacin and proglumide. These two substances are then released into the system in a 1:1 molar ratio.
Indometacin contributes to the anti-inflammatory effect, while proglumide hasantisecretory effects that helps prevent injury to the stomach lining.
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| n-arylanthranilic acids (fenamates) | |
| COX-2 inhibitors (coxibs) | |
| other | |
| NSAID combinations | |
Key:underline indicates initially developed first-in-class compound of specific group;#WHO-Essential Medicines;†withdrawn drugs;‡veterinary use. | |
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