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| Clinical data | |
|---|---|
| Trade names | Meptin, others |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Routes of administration | Oral (tablets,syrup), inhalation (DPI) |
| ATC code | |
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| PubChemCID | |
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| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.069.606 |
| Chemical and physical data | |
| Formula | C16H22N2O3 |
| Molar mass | 290.363 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
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Procaterol is aβ2 adrenoreceptor agonist used for the treatment ofasthma in many countries, but is not approved in theUnited States. The drug is readilyoxidized in the presence of moisture and air, and requires stabilizers for use by inhalation.[1]
It was patented in 1974 and came into medical use in 1980.[2] Procaterol is similar tosalbutamol (albuterol), but has a somewhat more prolonged action. It can be taken orally or by inhalation to treat asthma.
8-Hydroxycarbostyril1 is acylated with 2-bromobutyric acid chloride2 at the fifth position of the quinoline system, which gives the compound3. This undergoes action of isopropylamine, forming an aminoketone, the carbonyl group of which is reduced by sodium borohydride, giving procaterol4.[3][4][5][6]
It is also known as procaterol hydrochloride (USAN).
Procaterol is available under a number of trade names (Onsukil, Masacin, Procadil and others).[7]
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