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Presepsin

From Wikipedia, the free encyclopedia
Biomarker for the diagnosis of infections

Presepsin (soluble CD14 subtype,sCD14-ST) is a 13-kDa-cleavage product ofCD14 receptor.[1]

Function

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Presepsin is a solublePRR. Presepsin in the circulation is an indicator of monocyte-macrophage activation in response to pathogens.[1]

Clinical relevance

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Several clinical studies have demonstrated that presepsin is a specific and sensitive marker for the diagnosis, severity assessment and outcome prediction ofsepsis.[2][3][4] In addition, presepsin can be used for diagnosing infections in patients with a chronic inflammatory condition, such as livercirrhosis.[5]

References

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  1. ^abChenevier-Gobeaux C, Borderie D, Weiss N, Mallet-Coste T, Claessens YE (October 2015). "Presepsin (sCD14-ST), an innate immune response marker in sepsis".Clinica Chimica Acta; International Journal of Clinical Chemistry.450:97–103.doi:10.1016/j.cca.2015.06.026.PMID 26164388.
  2. ^Dupuy AM, Philippart F, Péan Y, Lasocki S, Charles PE, Chalumeau M, et al. (July 2013)."Role of biomarkers in the management of antibiotic therapy: an expert panel review: I - currently available biomarkers for clinical use in acute infections".Annals of Intensive Care.3 (1): 22.doi:10.1186/2110-5820-3-22.PMC 3708786.PMID 23837559.
  3. ^Tong X, Cao Y, Yu M, Han C (2015)."Presepsin as a diagnostic marker for sepsis: evidence from a bivariate meta-analysis".Therapeutics and Clinical Risk Management.11:1027–33.doi:10.2147/TCRM.S84811.PMC 4494627.PMID 26170681.
  4. ^Wu J, Hu L, Zhang G, Wu F, He T (2015)."Accuracy of Presepsin in Sepsis Diagnosis: A Systematic Review and Meta-Analysis".PLOS ONE.10 (7): e0133057.Bibcode:2015PLoSO..1033057W.doi:10.1371/journal.pone.0133057.PMC 4507991.PMID 26192602.
  5. ^Papp M, Tornai T, Vitalis Z, Tornai I, Tornai D, Dinya T, et al. (November 2016)."Presepsin teardown - pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis".World Journal of Gastroenterology.22 (41):9172–9185.doi:10.3748/wjg.v22.i41.9172.PMC 5107598.PMID 27895404.
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