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Potassium channel opener

From Wikipedia, the free encyclopedia
Type of drug

Apotassium channel opener is a type ofdrug which facilitatesion transmission throughpotassium channels.[1]

Examples

[edit]

Some examples include:[1]

ClassSubclassesActivators
Calcium-activated

6T & 1P

[citation needed]
Inwardly rectifying

2T & 1P

[citation needed]
  • none
[citation needed]
[citation needed]
Tandem pore domain

4T & 2P

[citation needed]
Voltage-gated

6T & 1P

See also

[edit]

References

[edit]
  1. ^abJahangir A, Terzic A, Shen WK (December 2001). "Potassium channel openers: therapeutic potential in cardiology and medicine".Expert Opin Pharmacother.2 (12):1995–2010.doi:10.1517/14656566.2.12.1995.PMID 11825331.
  2. ^Mizutani S, Prasad SM, Sellitto AD, Schuessler RB, Damiano RJ, Lawton JS (August 2005)."Myocyte volume and function in response to osmotic stress: observations in the presence of an adenosine triphosphate-sensitive potassium channel opener".Circulation.112 (9 Suppl): I219–23.doi:10.1161/CIRCULATIONAHA.104.523746.PMID 16159820.
  3. ^Wang T (February 2003). "The effects of the potassium channel opener minoxidil on renal electrolytes transport in the loop of henle".J. Pharmacol. Exp. Ther.304 (2):833–40.doi:10.1124/jpet.102.043380.PMID 12538840.S2CID 6948410.
  4. ^Sudo H, Yogo K, Ishizuka N, Otsuka H, Horie S, Saito K (November 2008)."Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction".Biol. Pharm. Bull.31 (11):2079–82.doi:10.1248/bpb.31.2079.PMID 18981577.
  5. ^Stojnic N, Gojkovic-Bukarica L, Peric M, et al. (June 2007)."Potassium channel opener pinacidil induces relaxation of the isolated human radial artery".J. Pharmacol. Sci.104 (2):122–9.doi:10.1254/jphs.FP0061434.PMID 17538231.[dead link]
  6. ^Rundfeldt C (October 1997). "The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells".European Journal of Pharmacology.336 (2–3):243–9.doi:10.1016/S0014-2999(97)01249-1.PMID 9384239.
  7. ^Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, Burbidge SA (August 2000). "Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine".Molecular Pharmacology.58 (2):253–62.doi:10.1124/mol.58.2.253.PMID 10908292.S2CID 11112809.
  8. ^abcdefEnyedi P, Czirják G (Apr 2010)."Molecular background of leak K+ currents: two-pore domain potassium channels"(PDF).Physiological Reviews.90 (2):559–605.doi:10.1152/physrev.00029.2009.PMID 20393194.S2CID 9358238.
  9. ^abcdefLotshaw DP (2007). "Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels".Cell Biochemistry and Biophysics.47 (2):209–56.doi:10.1007/s12013-007-0007-8.PMID 17652773.S2CID 12759521.
  10. ^abFink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M (Jun 1998)."A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids".The EMBO Journal.17 (12):3297–308.doi:10.1093/emboj/17.12.3297.PMC 1170668.PMID 9628867.
  11. ^Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (Mar 2001)."Potassium leak channels and the KCNK family of two-P-domain subunits".Nature Reviews. Neuroscience.2 (3):175–84.doi:10.1038/35058574.PMID 11256078.S2CID 9682396.
  12. ^Sano Y, Inamura K, Miyake A, Mochizuki S, Kitada C, Yokoi H, Nozawa K, Okada H, Matsushime H, Furuichi K (Jul 2003)."A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord".The Journal of Biological Chemistry.278 (30):27406–12.doi:10.1074/jbc.M206810200.PMID 12754259.S2CID 22656809.
  13. ^Czirják G, Tóth ZE, Enyedi P (Apr 2004)."The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin"(PDF).The Journal of Biological Chemistry.279 (18):18550–8.doi:10.1074/jbc.M312229200.PMID 14981085.S2CID 21219622.
  14. ^Meadows HJ, Randall AD (Mar 2001). "Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel".Neuropharmacology.40 (4):551–9.doi:10.1016/S0028-3908(00)00189-1.PMID 11249964.S2CID 20181576.
  15. ^Patel AJ, Honoré E, Lesage F, Fink M, Romey G, Lazdunski M (May 1999). "Inhalational anesthetics activate two-pore-domain background K+ channels".Nature Neuroscience.2 (5):422–6.doi:10.1038/8084.PMID 10321245.S2CID 23092576.
  16. ^Gray AT, Zhao BB, Kindler CH, Winegar BD, Mazurek MJ, Xu J, Chavez RA, Forsayeth JR, Yost CS (Jun 2000). "Volatile anesthetics activate the human tandem pore domain baseline K+ channel KCNK5".Anesthesiology.92 (6):1722–30.doi:10.1097/00000542-200006000-00032.PMID 10839924.S2CID 45487917.
  17. ^Rogawski MA, Bazil CW (Jul 2008)."New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels".Current Neurology and Neuroscience Reports.8 (4):345–52.doi:10.1007/s11910-008-0053-7.PMC 2587091.PMID 18590620.
  18. ^Premoli I, Rossini PG, Goldberg PY, Posadas K, Green L, Yogo N, Pimstone S, Abela E, Beatch GN, Richardson MP (November 2019)."TMS as a pharmacodynamic indicator of cortical activity of a novel anti-epileptic drug, XEN1101".Annals of Clinical and Translational Neurology.6 (11):2164–2174.doi:10.1002/acn3.50896.PMC 6856596.PMID 31568714.XEN1101 is a novel positive allosteric modulator ("opener") of the potassium channel KCNQ2/3 (Kv7.2/7.3) currently being developed by Xenon Pharmaceuticals Inc. for the treatment of focal epilepsy.
Types
Classes
Enzyme
Ion channel
Receptor &
transporter
BA/M
Adrenergic
Dopaminergic
Histaminergic
Serotonergic
AA
GABAergic
Glutamatergic
Cholinergic
Cannabinoidergic
Opioidergic
Other
Miscellaneous
Calcium
VDCCsTooltip Voltage-dependent calcium channels
Blockers
Activators
Potassium
VGKCsTooltip Voltage-gated potassium channels
Blockers
Activators
IRKsTooltip Inwardly rectifying potassium channel
Blockers
Activators
KCaTooltip Calcium-activated potassium channel
Blockers
Activators
K2PsTooltip Tandem pore domain potassium channel
Blockers
Activators
Sodium
VGSCsTooltip Voltage-gated sodium channels
Blockers
Activators
ENaCTooltip Epithelial sodium channel
Blockers
Activators
ASICsTooltip Acid-sensing ion channel
Blockers
Chloride
CaCCsTooltip Calcium-activated chloride channel
Blockers
Activators
CFTRTooltip Cystic fibrosis transmembrane conductance regulator
Blockers
Activators
Unsorted
Blockers
Others
TRPsTooltip Transient receptor potential channels
LGICsTooltip Ligand gated ion channels
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