 | |
| Names | |
|---|---|
| IUPAC name Trisodium (8Z)-7-oxo-8-[(4-sulfonatonaphthalen-1-yl)hydrazinylidene]naphthalene-1,3-disulfonate | |
| Identifiers | |
3D model (JSmol) | |
| ChemSpider |
|
| ECHA InfoCard | 100.018.216 |
| E number | E124(colours) |
| UNII | |
| |
| |
| Properties | |
| C20H11N2Na3O10S3 | |
| Molar mass | 604.46 g·mol−1 |
| Hazards | |
| NFPA 704 (fire diamond) | |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Ponceau 4R (known by more than 100 synonyms,[1]: 460–461 including asC.I. 16255,[2]cochineal red A,[2]C.I. acid red 18,[2]brilliant scarlet 3R,[2]brilliant scarlet 4R,[2]new coccine,[1]: 460 ) is asynthetic colourant that may be used as afood colouring. It is denoted byE NumberE124.[2] Its chemical name is 1-(4-sulfo-1-napthylazo)-2-napthol-6,8-disulfonic acid, trisodium salt.Ponceau (17th centuryFrench for "poppy-coloured") is the generic name for a family ofazo dyes.
Ponceau 4R is a strawberry redazo dye which can be used in a variety of food products, and is usually synthesized fromaromatic hydrocarbons; it is stable to light, heat, and acid but fades in the presence of ascorbic acid.[1]: 460
It is used in Europe, Asia, and Australia, but has not been approved for human consumption by theUnited States Food and Drug Administration.[1]: 460 [2]
There is no evidence of carcinogenicity, genotoxicity, neurotoxicity, or reproductive and developmental toxicity at the permitted dietary exposures; the Europeanacceptable daily intake (ADI) is 0.7 mg/kg and the WHO/FAO ADI is 4 mg/kg.[1]: 460
The production process may result in unsulfonatedaromatic amines present in concentrations of up to 100 mg/kg which may be linked tocancer. Thelake pigment form of the colour additive can also increase the intake ofaluminium beyond the tolerable weekly intake (TWI) of 1 mg/kg/week. Therefore, the limit for aluminium may be adjusted to accommodate for this.[3]
Since the 1970s and the well-publicized advocacy ofBenjamin Feingold, there has been public concern that food colourings may causeADHD-like behavior in children.[4] These concerns have led the FDA and other food safety authorities to regularly review the scientific literature, and led the UK FSA to commission a study by researchers at Southampton University of the effect of a mixture of six food dyes (Tartrazine,Allura Red AC, Ponceau 4R,Quinoline Yellow WS,Sunset Yellow andCarmoisine, dubbed the "Southampton 6") andsodium benzoate (a preservative) on children in the general population, who consumed them in beverages; the study published in 2007.[4][5] The study found "a possible link between the consumption of these artificial colours and a sodium benzoate preservative and increased hyperactivity" in the children;[4][5] the advisory committee to the FSA that evaluated the study also determined that because of study limitations, the results could not be extrapolated to the general population, and further testing was recommended.[4]
The European regulatory community, with a stronger emphasis on theprecautionary principle, required labelling and temporarily reduced theacceptable daily intake (ADI) for the food colourings; the UK FSA called for voluntary withdrawal of the colourings by food manufacturers.[4][5] However, in 2009 the EFSA re-evaluated the data at hand and determined that "the available scientific evidence does not substantiate a link between the colour additives and behavioural effects".[3][4]
There is no evidence to support broad claims that food colouring causesfood intolerance andADHD-like behaviour in children.[6]: 452 It is possible that certain food colouring may act as a trigger in those who are genetically predisposed, but the evidence is weak.[4][7]
