| Polo kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.11.21 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDBPDBePDBsum | ||||||||
| |||||||||
Inenzymology, apolo kinase (EC2.7.11.21) is akinaseenzyme i.e. one thatcatalyzes thechemical reaction
Thus, the twosubstrates of these enzymes areATP andprotein, whereas their twoproducts areADP andphosphoprotein.
These enzymes belong to the family oftransferases, specifically those transferring a phosphate group to the sidechainoxygen atom ofserine orthreonine residues inproteins (protein-serine/threonine kinases).
Thesystematic name of this [polo[-like] kinase] enzyme class isATP:protein phosphotransferase (spindle-pole-dependent).
Examples and other names in common use includeCdc5,Cdc5p,Plk,PLK,Plk1,Plo1,POLO kinase,polo serine-threonine kinase,polo-like kinase,polo-like kinase 1,serine/threonine-specific Drosophila kinase polo, andSTK21.
These enzymes participate in 3metabolic pathways:cell cycle,cell cycle - yeast, andprogesterone-mediated oocyte maturation.
As of late 2007, 5structures have been solved for this class of enzymes, withPDB accession codes2OGQ,2OJS,2OJX,2OU7, and2OWB.
