Released pneumolysin will aid the bacteria during colonization by facilitating adherence to the host,[5] during invasion by damaging host cells[6] and during infection by interfering with the host immune response.[7]
^Rossjohn, J; Gilbert, RJ; Crane, D; Morgan, PJ; et al. (Nov 27, 1998). "The molecular mechanism of pneumolysin, a virulence factor fromStreptococcus pneumoniae".Journal of Molecular Biology.284 (2):449–61.doi:10.1006/jmbi.1998.2167.PMID9813129.
^Marriott, HM; Mitchell, TJ; Dockrell, DH (September 2008). "Pneumolysin: A double-edged sword during the host-pathogen interaction".Current Molecular Medicine.8 (6):497–509.doi:10.2174/156652408785747924.PMID18781957.
^Baba, H; Kawamura, I; Kohda, C; Nomura, T; et al. (February 16, 2001). "Essential role of domain 4 of pneumolysin fromStreptococcus pneumoniae in cytolytic activity as determined by truncated proteins".Biochemical and Biophysical Research Communications.281 (1):37–44.doi:10.1006/bbrc.2001.4297.PMID11178957.
^Cockeran, R; Anderson, R; Feldman, C (June 2002). "The role of pneumolysin in the pathogenesis ofStreptococcus pneumoniae infection".Current Opinion in Infectious Diseases.15 (3):235–9.doi:10.1097/00001432-200206000-00004.PMID12015456.
^Wheeler, J; Freeman, R; Steward, M; Henderson, K; et al. (September 1999). "Detection of pneumolysin in sputum".Journal of Medical Microbiology.48 (9):863–6.doi:10.1099/00222615-48-9-863.PMID10482298.
^Rajalakshmi, B; Kanungo, R; Srinivasan, S; Badrinath, S (Oct–Dec 2002). "Pneumolysin in urine: A rapid antigen detection method to diagnose pneumococcal pneumonia in children".Indian Journal of Medical Microbiology.20 (4):183–6.PMID17657067.
