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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| ECHA InfoCard | 100.046.887 |
| Chemical and physical data | |
| Formula | C16H24N2O6 |
| Molar mass | 340.376 g·mol−1 |
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Pirisudanol (Mentis,Menthen,Mentium,Nadex,Nadexen,Nadexon,Pridana,Stivane), also known aspyrisuccideanol, is thesuccinic acidester ofpyridoxine (a form ofvitamin B6) and ofdeanol (DMAE).[1] It has been used inEurope in the treatment of mildcognitive impairment as well asfatigue anddepression.[1][2][3][4][5]
Pirisudanol is synthesized by the following method:[6][7]
Cyclic ketal formation between pyridoxine [33605-94-6] HCl: [58-56-0] (1) and acetone resulted in alpha4,3-O-Isopropylidene Pyridoxine [1136-52-3] (2). In the other arm of the synthesis succinic anhydride [108-30-5] (3) is then esterified with Deanol [108-01-0] (4) gives Yakton [10549-59-4] (5). Halogenation of the remaining carboxyl group with thionyl chloride gives PC135056269 (6). In a convergent synthesis, esterification between 2 and 6 gives 7. The last step consists of deblocking the protecting group by hydrolysis with 1% formic acid in ethanol to give the product (8).
(uv, ir, pmr, ms):[8]
