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Pindobind

From Wikipedia, the free encyclopedia
Pindobind
Names
IUPAC name
2-Bromo-N-[4-(2-{[2-hydroxy-3-(1H-indol-4-yloxy)propyl]amino}-2-propanyl)-1-methylcyclohexyl]acetamide
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C23H34BrN3O3/c1-22(2,16-7-10-23(3,11-8-16)27-21(29)13-24)26-14-17(28)15-30-20-6-4-5-19-18(20)9-12-25-19/h4-6,9,12,16-17,25-26,28H,7-8,10-11,13-15H2,1-3H3,(H,27,29)
    Key: XSAGAZCYTLNCEN-UHFFFAOYSA-N
  • InChI=1/C23H34BrN3O3/c1-22(2,16-7-10-23(3,11-8-16)27-21(29)13-24)26-14-17(28)15-30-20-6-4-5-19-18(20)9-12-25-19/h4-6,9,12,16-17,25-26,28H,7-8,10-11,13-15H2,1-3H3,(H,27,29)
    Key: XSAGAZCYTLNCEN-UHFFFAOYAL
  • BrCC(=O)NC1(C)CCC(CC1)C(NCC(O)COc2cccc3c2cc[nH]3)(C)C
Properties
C23H34BrN3O3
Molar mass480.447 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

Pindobind is a compound developed by researchers associated withStanford University,[1] identified as acentral nervous systemdepressant,[2] which generated a response in animals reducing offensive actions such as chasing, while also notably reducing tendencies of the test animal to evade when stimulated to do so.[2] It acts as anirreversiblebeta blocker and irreversible5-HT1A receptorantagonist.

See also

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References

[edit]
  1. ^Peroutka, Stephen J.; Pitha, Josef (Jul 20, 1993),Method for relieving anxiety using 5-hydroxytryptamine-1a-receptor-binding compounds, retrieved2016-06-04
  2. ^abBell, R; Hobson, H (1993). "Effects of pindobind 5-hydroxytryptamine1A (5-HT1A), a novel and potent 5-HT1A antagonist, on social and agonistic behaviour in male albino mice".Pharmacology Biochemistry and Behavior.46 (1):67–72.doi:10.1016/0091-3057(93)90318-N.PMID 8255924.
β, non-selective
β1-selective
β2-selective
α1- + β-selective
α1
Agonists
Antagonists
α2
Agonists
Antagonists
β
Agonists
Antagonists
5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
5-HT2
5-HT2A
5-HT2B
5-HT2C
5-HT3–7
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7
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