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Picotamide

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Picotamide
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 4-methoxy-N,N'-bis(pyridin-3-ylmethyl)isophthalamide
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
ECHA InfoCard100.046.572Edit this at Wikidata
Chemical and physical data
FormulaC21H20N4O3
Molar mass376.416 g·mol−1
3D model (JSmol)
  • O=C(NCc1cccnc1)c3cc(C(=O)NCc2cccnc2)c(OC)cc3
  • InChI=1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27) checkY
  • Key:KYWCWBXGRWWINE-UHFFFAOYSA-N checkY
  (verify)

Picotamide is aplatelet aggregation inhibitor. It works as athromboxane synthase inhibitor and athromboxane receptor inhibitor, the latter by modifying cellular responses to activation of thethromboxane receptor.[1] Picotamide is licensed in Italy for the treatment of clinical arterial thrombosis and peripheral artery disease.[2]

References

[edit]
  1. ^Ratti S, Quarato P, Casagrande C, Fumagalli R, Corsini A (August 1998). "Picotamide, an antithromboxane agent, inhibits the migration and proliferation of arterial myocytes".European Journal of Pharmacology.355 (1):77–83.doi:10.1016/S0014-2999(98)00467-1.PMID 9754941.
  2. ^Capra V, Bäck M,Angiolillo DJ, Cattaneo M, Sakariassen KS (February 2014)."Impact of vascular thromboxane prostanoid receptor activation on hemostasis, thrombosis, oxidative stress, and inflammation".Journal of Thrombosis and Haemostasis.12 (2):126–137.doi:10.1111/jth.12472.PMID 24298905.

Further reading

[edit]
Antiplatelet drugs
Glycoprotein IIb/IIIa inhibitors
ADP receptor/P2Y12inhibitors
Prostaglandin analogue (PGI2)
COX inhibitors
Thromboxane inhibitors
Phosphodiesterase inhibitors
Other
Anticoagulants
Vitamin K antagonists
(inhibitII,VII,IX,X)
Factor Xa inhibitors
(with some II inhibition)
Heparin group/
glycosaminoglycans/
(bindantithrombin)
Direct Xa inhibitors ("xabans")
Direct thrombin (IIa) inhibitors
Other
Thrombolytic drugs/
fibrinolytics
Non-medicinal
Receptor
(ligands)
DP (D2)Tooltip Prostaglandin D2 receptor
DP1Tooltip Prostaglandin D2 receptor 1
DP2Tooltip Prostaglandin D2 receptor 2
EP (E2)Tooltip Prostaglandin E2 receptor
EP1Tooltip Prostaglandin EP1 receptor
EP2Tooltip Prostaglandin EP2 receptor
EP3Tooltip Prostaglandin EP3 receptor
EP4Tooltip Prostaglandin EP4 receptor
Unsorted
FP (F2α)Tooltip Prostaglandin F receptor
IP (I2)Tooltip Prostacyclin receptor
TP (TXA2)Tooltip Thromboxane receptor
Unsorted
Enzyme
(inhibitors)
COX
(PTGS)
PGD2STooltip Prostaglandin D synthase
PGESTooltip Prostaglandin E synthase
PGFSTooltip Prostaglandin F synthase
PGI2STooltip Prostacyclin synthase
TXASTooltip Thromboxane A synthase
Others
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