 | |
| Names | |
|---|---|
| IUPAC name (1R)-1,4-Anhydro-1-(N2-formylglycinamido)-D-ribitol 5-(dihydrogen phosphate) | |
| Systematic IUPAC name [(2R,3S,4R,5R)-5-(2-Formamidoacetamido)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate | |
| Other names Formylglycinamide ribonucleotide, Formylglycinamide ribotide, FGAR | |
| Identifiers | |
| |
3D model (JSmol) | |
| ChemSpider |
|
| MeSH | Phosphoribosyl-N-formylglycineamide |
| |
| |
| Properties | |
| C8H15N2O9P | |
| Molar mass | 314.187 g/mol |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Phosphoribosyl-N-formylglycineamide (orFormylGlycinAmideRibotide, FGAR) is a biochemical intermediate in the formation ofpurinenucleotides viainosine-5-monophosphate, and hence is a building block forDNA andRNA.[1][2] The vitaminsthiamine[3] andcobalamin[4] also contain fragments derived from FGAR.[5]
FGAR is formed when the enzymephosphoribosylglycinamide formyltransferase adds aformyl group from10-formyltetrahydrofolate toglycineamide ribonucleotide (GAR) in reactionEC2.1.2.2:[6]
The biosynthesis pathway next converts FGAR to anamidine by the action ofphosphoribosylformylglycinamidine synthase (EC6.3.5.3), transferring an amino group from glutamine and giving5'-phosphoribosylformylglycinamidine (FGAM) in a reaction that also requires ATP:[6]
