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Phosalone

From Wikipedia, the free encyclopedia
Phosalone
Names
Preferred IUPAC name
S-[(6-Chloro-2-oxo-1,3-benzoxazol-3(2H)-yl)methyl]O,O-diethyl phosphorodithioate
Other names
Zolone
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard100.017.270Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C12H15ClNO4PS2/c1-3-16-19(20,17-4-2)21-8-14-10-6-5-9(13)7-11(10)18-12(14)15/h5-7H,3-4,8H2,1-2H3 checkY
    Key: IOUNQDKNJZEDEP-UHFFFAOYSA-N checkY
  • InChI=1/C12H15ClNO4PS2/c1-3-16-19(20,17-4-2)21-8-14-10-6-5-9(13)7-11(10)18-12(14)15/h5-7H,3-4,8H2,1-2H3
    Key: IOUNQDKNJZEDEP-UHFFFAOYAA
  • Clc2ccc1c(OC(=O)N1CSP(=S)(OCC)OCC)c2
Properties
C12H15ClNO4PS2
Molar mass367.80 g·mol−1
AppearanceColorless crystalline
Odorgarlic
Density1.39 g cm−3
Melting point47.5 to 48 °C (117.5 to 118.4 °F; 320.6 to 321.1 K)
3.05 mg/L
Solubilitymany organic solvents
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Chemical compound

Phosalone is anorganophosphate chemical commonly used as aninsecticide andacaricide. It is developed byRhône-Poulenc in France but EU eliminated it from pesticide registration in December 2006.

Themedian lethal dose of oral exposure in rat is 85 mg/kg and that of dermal is 390 mg/kg.[1]。It is a weakacetylcholinesterase inhibitor.[2] It is taken by not only oral and inhalation but skin and it causes toxic symptoms peculiar toorganophosphorus compounds such asmiosis,hypersalivation,hyperhidrosis, chest pressure,pulmonary edema andfecal incontinence.[3] It is flammable and decomposes to toxic gases such asphosphorus oxides,sulfur oxides andnitrogen oxides.[2] It is harmful especially to water creatures.

References

[edit]
  1. ^製品安全データシート(安全衛生情報センター)Archived 2014-10-25 at theWayback Machine
  2. ^ab"国際化学物質安全性カード". Archived fromthe original on 2012-12-11. Retrieved2012-09-06.
  3. ^植村振作・河村宏・辻万千子・冨田重行・前田静夫著 (2002).農薬毒性の事典 改訂版. 三省堂.ISBN 978-4385356044.

External links

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Carbamates
Inorganic compounds
Insect growth regulators
Neonicotinoids
Organochlorides
Organophosphorus
Pyrethroids
Diamides
Other chemicals
Metabolites
Biopesticides
Enzyme
(modulators)
ChATTooltip Choline acetyltransferase
AChETooltip Acetylcholinesterase
BChETooltip Butyrylcholinesterase
Transporter
(modulators)
CHTTooltip Choline transporter
VAChTTooltip Vesicular acetylcholine transporter
Release
(modulators)
Inhibitors
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