Gilbert retired as a professional, after the2022 Paris–Tours.[11] He celebrated his retirement inValkenburg aan de Geul where he became world champion and won four Amstel Gold Races. He was honoured with a mural in the caves of theCauberg.[12]
In early 2007 he had a skin cancer lesion removed from his thigh,[20] delaying the start of his season. That did not stop him from trying himself duringMilan–San Remo, where he managed to escape on the Poggio withRiccardo Riccò before being captured 1.2 kilometres (0.75 miles) from the finishing line. He could not get any victory during the season until theTour du Limousin, where he claimed his only victory in 2007 by winning a stage. InParis–Tours he was caught with 500 metres (1,600 feet) to go along withKarsten Kroon andFilippo Pozzato.
Gilbert started 2008 by winning the King of the Mountains competition at theTour Down Under and the overall classification as well as two stages of theVuelta a Mallorca. He also finished third inMilan–San Remo, accomplishing his first podium in a monument. He later wonOmloop Het Volk for the second time in his career after a solo attack with almost 50 kilometres (31 miles) to go. Four days later he won theGP Samyn. He finished the year by winning the classicParis–Tours race in a late breakaway where he won a sprint between his three breakaway companions. The peloton finished four seconds back.
In 2009 he joinedSilence–Lotto to lead the Belgian team in the classics, finishing third at theTour of Flanders and fourth in both theAmstel Gold Race andLiège–Bastogne–Liège. He also took his first stage in aGrand Tour by winning the 20th stage of theGiro d'Italia[21] and won a stage and the overall classification of theSter Elektrotoer. Later in the season, he repeated hisParis–Tours win, attacking on the last climb withTom Boonen andBorut Božič before outsprinting them to the line. A week later, he also won the prestigiousGiro di Lombardia after escaping from the peloton withSamuel Sánchez, beating him to the finish by a half-length. It was his fourth victory in 10 days after also winning theCoppa Sabatini andGiro del Piemonte. At the end of the season, he was awarded theFlandrien of the Year award, recognising him as the best Belgian rider of the year.[22]
In 2010 he won his first classic of the year, April'sAmstel Gold Race. After an aggressive race featuring many attacks, he won through a big attack in the last 500 metres (1,600 feet) of the climb to the finish, comfortably winning by several bike lengths from the peloton.[23] He also won the first stage of theTour of Belgium. Gilbert then ended the 2010 season in superb form. He followed up two stage wins in theVuelta a España with victories in the Giro del Piemonte and the Giro di Lombardia, repeating his 2009 wins in both races. The Giro di Lombardia was won with a solo attack in atrocious weather conditions.[24]
In 2011, Gilbert won theMontepaschi Strade Bianche, a race including 70 kilometres (43 miles) ofgravel roads. He then had a quadruple consecutive win: first, he won theBrabantse Pijl, then he repeated as winner of theAmstel Gold Race, breaking free on the Cauberg. Three days later, he wonLa Flèche Wallonne dropping his rivals on the final climb of the Mur de Huy and finally, he wonLiège–Bastogne–Liège beating the Schleck brothers in the sprint. Gilbert thus became the second rider, afterDavide Rebellin in 2004, to win the three Ardennes classics in a single year.[25] During the first half of the season he also won stages at theVolta ao Algarve,Tirreno–Adriatico as well as the overall classification and a stage of both the Tour of Belgium andSter ZLM Toer.
In September, Gilbert won theGrand Prix Cycliste de Québec and took over the lead of the UCI world rankings with the 80 points awarded to the victor.[28] He followed that performance two days later at theGrand Prix Cycliste de Montréal by finishing third, despite stating that he felt "no pressure" after hisQuebec City victory. With that placing, Gilbert deposited another 50 UCI points in his account.[29] He would race in the October Italian classic, theGiro di Lombardia, taking eighth place after he was distanced on the final climb.[30] He eventually closed the season well ahead in theUCI World Tour rankings, with 718 points to the 584 points of his closest competitor, Cadel Evans.[31] He won 18 races in the season, more than any other cyclist in the professional peloton.[32]
Gilbert was appointed as a member of the inaugural UCI Athletes' Commission in 2011.[33]
In 2012, Gilbert signed forBMC Racing Team on a three-year contract reportedly worth €3 million a year.[34] His goals for his new squad were to perform highly in theSpring classics and help his team-mateCadel Evans repeat his 2011 feat of winning theTour de France.[32] Neither of those came to fruition, as Gilbert's best result in the one-day spring races was third atLa Flèche Wallonne, where he got deposited on the final climb byJoaquim Rodríguez who won atop the historicMur de Huy with a slim margin of 4 seconds.[35] Three days prior, he took sixth position at theAmstel Gold Race and was pleased to achieve a top ten ranking in theArdennes race.[36] He missed out on his goal to bring Evans in yellow to Paris and his best placing in a Tour de France stage was fourth.[32] He also lost both of the Belgian National Championship titles he held, finishing third in theBelgian National Time Trial Championships.[37]
On 26 August 2012, Gilbert finally managed his first victory of the season by winning the ninth stage of theVuelta a España after breaking away together with Rodríguez.[38] He later won a second stage of the race, winning stage nineteen on 7 September.[39]
In 2013, Gilbert headed towards the World Championships without a single win in the rainbow jersey, in danger of his first winless season since turning professional in 2003. He started theVuelta a España hoping that the competition would, for the second successive year, kick-start his season. After being narrowly defeated in a sprint byZdeněk Štybar onstage 7,[41] Gilbert finally clinched a victory in the rainbow stripes when he caught and passedEdvald Boasson Hagen to winstage 12.[42]
Gilbert finished third atBrabantse Pijl, seconds after his teammateBen Hermans.[43] At theAmstel Gold Race, Gilbert could not repeat his winning ways of 2014 and came in tenth after having attacked on the final climb of the day, the Cauberg.[44] On the next Wednesday, Gilbert crashed out ofLa Flèche Wallonne.[45] He then took part inLiège–Bastogne–Liège even though he was slightly injured and held on to the main group until the Côte de Saint-Nicolas, where he was dropped and finished 36th.[46] He scored his first victory of the season at theGiro d'Italia, besting the lead group on a sharp incline at the end of Stage 12.[47] He repeated on Stage 18, where he participated in the early break. After being dropped on the last climb of the day, he returned to the remnants of the breakaway after the descent and attacked them to win solo.[48]
Three days later, he won theTour of Flanders after a solo attack on theOude Kwaremont and holding off the rest of the field over the remaining 55 kilometres (34 mi).[54] Gilbert became the first rider in twenty years to win both theTour of Flanders andLiège–Bastogne–Liège in his career. Two weeks after that he won theAmstel Gold Race for a fourth time and became the third rider to win the Tour of Flanders and theAmstel Gold Race in the same year, afterJan Raas andEddy Merckx. It was later revealed that he won the race despite riding for the last 130 kilometres (81 mi) of the race with a minor kidney tear. The injury required treatment in hospital after the race, and ruled him out ofLa Flèche Wallonne and Liège–Bastogne–Liège.[55]
In Stage 16 of theTour de France, Gilbert was involved in a crash in a downhill section where he went over a wall, suffering lacerations and fracturing his kneecap. This was the same road whereFabio Casartelli died in the1995 Tour de France. Gilbert climbed back onto his bike and rode the remaining 57 kilometres (35 mi) to the finish inBagnères-de-Luchon, earning him the Most Combative Rider award but ending his tour.[56]
In April, Gilbert wonParis–Roubaix in a sprint ahead ofNils Politt, thereby raising his total number ofmonument titles to five.[57] During theVuelta a España, Gilbert won stage 12 toBilbao, after dropping his breakaway companions to reach the finish alone.[58] On stage 17 intoGuadalajara, Gilbert was again victorious. In a stage marked by crosswinds, his team forced the pace and allowed him to win the sprint finish. The average speed of 50.63 km/h (31.46 mph) marked the fastest ever road stage over 200 km (120 mi) in a Grand Tour.[59]
Gilbert was accused of abusingcortisone by an anonymous former Lotto teammate during his dominant period withOmega Pharma–Lotto, an allegation which the Belgian vehemently denies.[73]