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Phensuximide

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Chemical compound

Pharmaceutical compound

Phensuximide
Clinical data

MedlinePlus	a682237
ATC code	N03AD02 (WHO)
Pharmacokinetic data
Protein binding	21%
Identifiers
IUPAC name 1-methyl-3-phenyl-pyrrolidine-2,5-dione
CAS Number	86-34-0^Y
PubChemCID	6839
IUPHAR/BPS	7612
DrugBank	DB00832^Y
ChemSpider	6578^Y
UNII	6WVL9C355G
KEGG	D00508^Y
ChEMBL	ChEMBL797^Y
CompTox Dashboard(EPA)	DTXSID4023460
ECHA InfoCard	100.001.513
Chemical and physical data
Formula	C₁₁H₁₁NO₂
Molar mass	189.214 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C2N(C(=O)CC2c1ccccc1)C
InChI InChI=1S/C11H11NO2/c1-12-10(13)7-9(11(12)14)8-5-3-2-4-6-8/h2-6,9H,7H2,1H3^Y Key:WLWFNJKHKGIJNW-UHFFFAOYSA-N^Y
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Phensuximide is ananticonvulsant in thesuccinimide class.

Diseases Database (DDB):31648
Rankin G, Cressey-Veneziano K, Wang R, Brown P (1986). "Urinary tract effects of phensuximide in the Sprague-Dawley and Fischer 344 rat".J Appl Toxicol.6 (5):349–56.doi:10.1002/jat.2550060509.PMID 3772011.S2CID 40687770.

GABA_AR PAMs	Barbiturates:Barbexaclone Metharbital Methylphenobarbital Pentobarbital Phenobarbital^# Primidone;Carbamates:Cenobamate Felbamate;Benzodiazepines:Clobazam Clonazepam Clorazepate Diazepam^# Lorazepam^# Midazolam Nimetazepam Nitrazepam Temazepam;Others:Bromide (potassium bromide,sodium bromide) Imepitoin Paraldehyde Stiripentol
GABA-T inhibitors	Fatty acids (and related):Valproate Valpromide Valproate pivoxil Vigabatrin
Others	GABAR agonists:Progabide;GAT-1 inhibitors:Tiagabine

Sodium blockers	Hydantoins:Ethotoin Fosphenytoin Mephenytoin Phenytoin^#;Ureides:Acetylpheneturide Chlorphenacemide Phenacemide^‡ Pheneturide;Fatty acids:Valproate Valpromide Valproate pivoxil;Carboxamides: Carbamazepine^# Eslicarbazepine acetate Oxcarbazepine;Others:Lacosamide Lamotrigine^# Rufinamide Topiramate Zonisamide
Calcium blockers	Oxazolidinediones:Ethadione Paramethadione Trimethadione;Succinimides:Ethosuximide^# Mesuximide Phensuximide;Gabapentinoids:Gabapentin Pregabalin;Others:Imepitoin Lamotrigine^# Topiramate Zonisamide
Potassium openers	Retigabine

Others

CA inhibitors	Sulfonamides:Acetazolamide Ethoxzolamide Sultiame Topiramate Zonisamide
Others	Albutoin Beclamide Brivaracetam Cannabidiol Carisbamate Etiracetam Fenfluramine Ganaxolone Levetiracetam Perampanel

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