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Phenacemide

From Wikipedia, the free encyclopedia
Anticonvulsant

Pharmaceutical compound
Phenacemide
Clinical data
Trade namesPhenurone
AHFS/Drugs.comMicromedex Detailed Consumer Information
ATC code
Pharmacokinetic data
Eliminationhalf-life22–25 hours
Identifiers
  • N-Carbamoyl-2-phenyl-acetamide
CAS Number
PubChemCID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.000.519Edit this at Wikidata
Chemical and physical data
FormulaC9H10N2O2
Molar mass178.191 g·mol−1
3D model (JSmol)
  • O=C(NC(=O)N)Cc1ccccc1
  • InChI=1S/C9H10N2O2/c10-9(13)11-8(12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H3,10,11,12,13) checkY
  • Key:XPFRXWCVYUEORT-UHFFFAOYSA-N checkY
  (verify)

Phenacemide (INN,BAN) (brand namePhenurone), also known asphenylacetylurea, is ananticonvulsant of theureide (acetylurea) class.[1] It is acongener and ring-openedanalogue ofphenytoin (ahydantoin),[2][3] and is structurally related to thebarbiturates and to otherhydantoins.[4] Phenacemide was introduced in 1949 for the treatment ofepilepsy, but was eventually withdrawn due totoxicity.[2][3]

See also

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References

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  1. ^Ganellin CR, Triggle DJ (21 November 1996).Dictionary of Pharmacological Agents. CRC Press. pp. 1578–.ISBN 978-0-412-46630-4.
  2. ^abPrasad JP (2010)."Central Nervous System".Conceptual Pharmacology. Universities Press. pp. 236–.ISBN 978-81-7371-679-9.
  3. ^abSaxena AK, Saxena M (1995). "Developments in anticonvulsants". In deStevens G, Zingel V, Leschke C, Hoeprich P, Schultz R, Mehrotra P, et al. (eds.).Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Vol. 44. Basel: Birkhäuser. pp. 185–291.doi:10.1007/978-3-0348-7161-7_6.ISBN 978-3-0348-7161-7.PMID 7644666.{{cite book}}:|journal= ignored (help)
  4. ^Kadam SS, Mahadik KR, Bothara KG (1 July 2007)."Central Nervous System Depresants".Principles of Medicinal Chemistry. Vol. II. Pragati Books Pvt. Ltd. pp. 147–.ISBN 978-81-85790-03-9.

Further reading

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External links

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