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| Other names | Phemerazol; Femerazol; Femerazole; Phenylmethylpyrazole; 3-Methyl-5-phenylpyrazole |
| Drug class | Sedative;Hypnotic;Anticonvulsant;Muscle relaxant;Mammary stimulant |
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| ECHA InfoCard | 100.020.091 |
| Chemical and physical data | |
| Formula | C10H10N2 |
| Molar mass | 158.204 g·mol−1 |
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Phemerazole, orfemerazol, also known as5-phenyl-3-methylpyrazole, is asedativedrug andarylpyrazolederivative.[1][2][3][4][5] It produces sedative,hypnotic,hypolocomotive,antiaggressive,anticonvulsant,muscle relaxant, andhypothermic effects in animals.[1][2][6][7] In addition to itscentral nervous system effects, the drug has been found to potentiate the effects ofdiethylstilbestrol on themammary glands in animals, including producingductal andalveolarhyperplasia,stromalhyperemia, andlactogenesis.[1][4][5] Its effects in this regard were said to resemble those of the sedativeprolactin releaserschlorpromazine andreserpine.[4][5] The exactmechanisms of action of phemerazole in terms of its various effects do not appear to be known.[4][5] Phemerazole was first described in thescientific literature by 1960.[2][6][7] Various activeanalogues andderivatives of phemerazole are known.[1]
Phemerazole,3-methyl-5-phenylpyrazole (XL), was one of a group of pyrazoles which evoked sharply pronounced sedative, soporific, anticonvulsant, and hypothermic responses. [...] Phemerazole potentiated the action of diethylstilbestrol on mammary glands (250-254). [...] The versatility of action of even the simplest pyrazoles was noteworthy, and pyrazole, itself, was mentioned on several occasions. [...] The simple histamine isomer, betazole, manifested greater specificity on gastric secretions than histamine, while 3-methyl-5-phenylpyrazole, phemerazole, was an excellent central spasmolytic anticonvulsant.
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