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Pertine

From Wikipedia, the free encyclopedia
Chemical structure ofoxypertine, the most well-known drug of the pertine group.

Thepertines, also known asphenylpiperazinylethylindoles, are a group ofantipsychotics of thecyclized tryptamine andphenylpiperazine families that includes the followingdrugs:[1][2]

Oxypertine is known to show highaffinity for theserotonin5-HT2 anddopamineD2 receptors (Ki = 8.6 nM and 30 nM, respectively) and to also act as acatecholamine depleting agent.[2][3] Oxypertine, milipertine, and solypertine all antagonize the behavioral effects oftryptamine, aserotonin receptoragonist, andapomorphine, adopamine receptoragonist, in animals.[2][4]

Some of the pertines, like milipertine and solypertine, are notable in containing anNBOMe-likemoiety.[1][2]

The pertines were developed and initially described in the 1960s and 1970s.[1]

Chemical structures of pertines

See also

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References

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  1. ^abcElks, J. (14 November 2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer.ISBN 978-1-4757-2085-3. Retrieved18 June 2025.
  2. ^abcdMegens AA, Kennis LE (1996). "Risperidone and related 5HT2/D2 antagonists: a new type of antipsychotic agent?".Prog Med Chem. Progress in Medicinal Chemistry.33:185–232.doi:10.1016/s0079-6468(08)70306-0.ISBN 978-0-444-82310-6.PMID 8776944.
  3. ^Bak IJ, Hassler R, Kim JS (1969). "Differential monoamine depletion by oxypertine in nerve terminals. Granulated synaptic vesicles in relation to depletion of norepinephrine, dopamine and serotonin".Zeitschrift für Zellforschung und Mikroskopische Anatomie.101 (3):448–462.doi:10.1007/BF00335580.PMID 5362847.S2CID 32583722.
  4. ^Niemegeers CJ, Janssen PA (June 1979). "A systematic study of the pharmacological activities of dopamine antagonists".Life Sciences.24 (24). Elsevier BV:2201–2216.doi:10.1016/0024-3205(79)90096-1.PMID 388130.


Typical
Disputed
Atypical
Others
Tryptamines
4-Hydroxytryptamines
andesters/ethers
5-Hydroxy- and
5-methoxytryptamines
N-Acetyltryptamines
α-Alkyltryptamines
Cyclized tryptamines
Isotryptamines
Related compounds
Phenylpiperazines
Benzylpiperazines
Naphthylpiperazines
Quinolinylpiperazines
Diphenylalkylpiperazines
Pyrimidinylpiperazines
Pyridinylpiperazines
Benzo(iso)thiazolylpiperazines
Tricyclic-linked piperazines
Others/uncategorized


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