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Pentalenene oxygenase

From Wikipedia, the free encyclopedia
Pentalenene oxygenase
Identifiers
EC no.1.14.15.32
Databases
IntEnzIntEnz view
BRENDABRENDA entry
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MetaCycmetabolic pathway
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Pentalenene oxygenase (EC1.14.15.32, FormerlyEC1.14.13.133,PtlI) is anenzyme withsystematic namepentalenene,NADPH:oxygen 13-oxidoreductase.[1] This enzymecatalyses the followingchemical reaction

pentalenene + 2 NADPH + 2 H+ + 2 O2{\displaystyle \rightleftharpoons } pentalen-13-al + 2 NADP+ + 3 H2O (overall reaction)
(1a) pentalenene + NADPH + H+ + O2{\displaystyle \rightleftharpoons } pentalen-13-ol + NADP+ + H2O
(1b) pentalen-13-ol + NADPH + H+ + O2{\displaystyle \rightleftharpoons } pentalen-13-al + NADP+ + 2 H2O

Pentaleneneoxygenase is aheme-thiolate protein (P-450).

References

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  1. ^Quaderer R, Omura S, Ikeda H, Cane DE (October 2006)."Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlI, a cytochrome P450 of Streptomyces avermitilis".Journal of the American Chemical Society.128 (40):13036–7.Bibcode:2006JAChS.12813036Q.doi:10.1021/ja0639214.PMC 2533730.PMID 17017767.

External links

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CYP1
CYP2
CYP3 (CYP3A)
CYP4
CYP5-20
CYP21-49
CYP51-69
CYP71-99
CYP101-281
CYP301-499
CYP501-699
CYP701-999
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