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Pateclizumab

From Wikipedia, the free encyclopedia
Monoclonal antibody
Pharmaceutical compound
Pateclizumab
Monoclonal antibody
TypeWhole antibody
SourceHumanized (frommouse)
Targetlymphotoxin alpha
Clinical data
Other namesMLTA3698A
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6436H9910N1710O2004S44
Molar mass144716.68 g·mol−1
 ☒NcheckY (what is this?)  (verify)

Pateclizumab (MLTA3698A) is an immunomodulator. It binds tolymphotoxin alpha.[1][2][3][4][5][6]

This drug was developed byGenentech/Roche.

References

[edit]
  1. ^World Health Organization (2011)."International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 105"(PDF).WHO Drug Information.25 (2).[dead link]
  2. ^Statement On A Nonproprietary Name Adopted By The USAN Council - Pateclizumab,American Medical Association.
  3. ^Kennedy WP, Simon JA, Offutt C, Horn P, Herman A, Townsend MJ, Tang MT, Grogan JL, Hsieh F, Davis JC (October 2014)."Efficacy and safety of pateclizumab (anti-lymphotoxin-α) compared to adalimumab in rheumatoid arthritis: a head-to-head phase 2 randomized controlled study (The ALTARA Study)".Arthritis Res. Ther.16 (5): 467.doi:10.1186/s13075-014-0467-3.PMC 4243296.PMID 25359150.
  4. ^Emu B, Luca D, Offutt C, Grogan JL, Rojkovich B, Williams MB, Tang MT, Xiao J, Lee JH, Davis JC (January 2012)."Safety, pharmacokinetics, and biologic activity of pateclizumab, a novel monoclonal antibody targeting lymphotoxin α: results of a phase I randomized, placebo-controlled trial".Arthritis Res. Ther.14 (1): R6.doi:10.1186/ar3554.PMC 3392792.PMID 22225620.
  5. ^Wang H, Schuetz C, Arima A, Chihaya Y, Weinbauer GF, Habermann G, Xiao J, Woods C, Grogan J, Gelzleichter T, Cain G (August 2016). "Assessment of placental transfer and the effect on embryo-fetal development of a humanized monoclonal antibody targeting lymphotoxin-alpha in non-human primates".Reprod. Toxicol.63:82–95.doi:10.1016/j.reprotox.2016.05.014.PMID 27211603.S2CID 41454952.
  6. ^Hirose T, Fukuma Y, Takeshita A, Nishida K (June 2018). "The role of lymphotoxin-α in rheumatoid arthritis".Inflamm. Res.67 (6):495–501.doi:10.1007/s00011-018-1139-6.PMID 29541795.S2CID 3910200.


Immune system
Human
Mouse
Chimeric
Humanized
Chimeric + humanized
Interleukin
Human
Humanized
Veterinary
Inflammatorylesions
Mouse
CC
CCR1
CCR2
CCR3
CCR4
CCR5
CCR6
CCR7
CCR8
CCR9
CCR10
CCR11
Ungrouped
CXC
CXCR1
(IL-8Rα)
CXCR2
(IL-8Rβ)
CXCR3
CXCR4
CXCR5
CXCR6
CXCR7
C (XC)
XCR1
CX3C
CX3CR1
Others
CCBP2
CMKLR1


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