Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

Panomifene

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Panomifene
Clinical data
Other namesGYKI-13504; EGIS-5650
Identifiers
  • 2-[2-[4-[(E)-3,3,3-trifluoro-1,2-diphenylprop-1-enyl]phenoxy]ethylamino]ethanol
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC25H24F3NO2
Molar mass427.467 g·mol−1
3D model (JSmol)
  • C1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\C(F)(F)F)/C3=CC=C(C=C3)OCCNCCO
  • InChI=1S/C25H24F3NO2/c26-25(27,28)24(21-9-5-2-6-10-21)23(19-7-3-1-4-8-19)20-11-13-22(14-12-20)31-18-16-29-15-17-30/h1-14,29-30H,15-18H2/b24-23+
  • Key:MHXVDXXARZCVRK-WCWDXBQESA-N

Panomifene (INN; developmental codesGYKI 13504 andEGIS 5650) is anonsteroidalselective estrogen receptor modulator (SERM) of thetriphenylethylene group related totamoxifen that was under development as anantineoplastic agent by Egis Pharmaceuticals and IVAX Drug Research Institute in the 1990s for the treatment ofbreast cancer, but it was never marketed.[1][2][3][4][5][6] It reachedphase IIclinical trials before development was terminated.[2] The drug was described in 1981.[1]

References

[edit]
  1. ^abElks J (14 November 2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 930–.ISBN 978-1-4757-2085-3.
  2. ^ab"Panomifene".AdisInsight. Springer Nature Switzerland AG.
  3. ^von Angerer E (6 December 2012)."Antiestrogens and Partial Agonists". In Oettel M, Schillinger E (eds.).Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. Springer Science & Business Media. pp. 60–.ISBN 978-3-642-58616-3.
  4. ^Sitruk-Ware R (6 December 2012)."Pharmacological Different Administration Routes - Oral vs Transdermal". In Oettel M, Schillinger E (eds.).Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen. Springer Science & Business Media. pp. 292–.ISBN 978-3-642-60107-1.
  5. ^Koike T, Akita M (18 October 2014)."Visible-Light-Induced Redox Reactions by Ruthenium Photoredox Catalyst". In Dixneuf PH, Bruneau C (eds.).Ruthenium in Catalysis. Springer. pp. 385–.ISBN 978-3-319-08482-4.
  6. ^Borvendég J, Hermann I, Csuka O (1996). "Antiestrogens, antiandrogens".Acta Physiologica Hungarica.84 (4):405–406.PMID 9328614.
ERTooltip Estrogen receptor
Agonists
Mixed
(SERMsTooltip Selective estrogen receptor modulators)
Antagonists
GPERTooltip G protein-coupled estrogen receptor
Agonists
Antagonists
Unknown
Stub icon

Thisantineoplastic orimmunomodulatorydrug article is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Panomifene&oldid=1294253783"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2025 Movatter.jp