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PTI-3

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
PTI-3
Legal status
Legal status
Identifiers
  • N-({2-[1-(5-fluoropentyl)-1H-indol-3-yl]-1,3-thiazol-4-yl}methyl)-2-methoxy-N-methylethanamine
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC21H28FN3OS
Molar mass389.53 g·mol−1
3D model (JSmol)
  • COCCN(C)Cc1csc(n1)c1cn(CCCCCF)c2ccccc21
  • InChI=1S/C21H28FN3OS/c1-24(12-13-26-2)14-17-16-27-21(23-17)19-15-25(11-7-3-6-10-22)20-9-5-4-8-18(19)20/h4-5,8-9,15-16H,3,6-7,10-14H2,1-2H3
  • Key:LXQIIHJBHSFWQW-UHFFFAOYSA-N

PTI-3 is anindole-3-thiazole basedsynthetic cannabinoid which has been sold as adesigner drug.[1] It was first identified in Hungary in 2020,[2] and was made illegal in Italy in June 2021.[3]

See also

[edit]


References

[edit]
  1. ^Malaca S, Tini A, Umani Ronchi F (January 2022)."Fourth generation of synthetic cannabinoid receptor agonists: a summary on the latest insights".Acta Bio-Medica.92 (6): e2021546.doi:10.23750/abm.v92i6.12696.PMC 8823589.PMID 35075053.
  2. ^European Monitoring Center for Drugs and Drug Addiction (December 2020).New psychoactive substances: global markets, glocal threats and the COVID-19 pandemic. An update from the EU Early Warning System(PDF). Luxembourg: Publications Office of the European Union.doi:10.2810/921262.ISBN 9789294975584.
  3. ^"Decreto 1 Giugno 2021. Aggiornamento delle tabelle contenenti l'indicazione delle sostanze stupefacenti e psicotrope, di cui al decreto del Presidente della Repubblica 9 ottobre 1990, n. 309 e successive modificazioni e integrazioni. Inserimento nella tabella I di nuove sostanze psicoattive. (21A03590) (GU Serie Generale n.144 del 18-06-2021)" [Decree of 1 June 2021. Update of the tables containing the indication of narcotic and psychotropic substances, as per the decree of the President of the Republic of 9 October 1990, n. 309 and subsequent amendments and additions. Inclusion in Table I of new psychoactive substances. (21A03590) (GU General Series n.144 of 18-06-2021] (in Italian).


Phytocannabinoids
(comparison)
Cannabibutols
Cannabichromenes
Cannabicyclols
Cannabidiols
Cannabielsoins
Cannabigerols
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Delta-9-tetrahydrocannabinols
Delta-10-Tetrahydrocannabinols
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Miscellaneous cannabinoids
Active metabolites
Endocannabinoids
Synthetic
cannabinoid
receptor
agonists /
neocannabinoids
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(dibenzopyrans)
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cannabinoids
Adamantoylindoles
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AllostericCBRTooltip Cannabinoid receptorligands
Endocannabinoid
enhancers

(inactivation inhibitors)
Anticannabinoids
(antagonists/inverse
agonists/antibodies)
Receptor
(ligands)
CB1Tooltip Cannabinoid receptor type 1
Agonists
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NAGly
(
GPR18)
Agonists
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Agonists
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eCBTsTooltip Endocannabinoid transporter
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FAAHTooltip Fatty acid amide hydrolase
MAGL
ABHD6
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  • Others:2-PG(directly potentiates activity of 2-AG at CB1 receptor)
  • ARN-272(FAAH-like anandamide transporter inhibitor)
See also
Receptor/signaling modulators
Cannabinoids (cannabinoids by structure)
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