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PRSS22

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

PRSS22

Identifiers

Aliases

PRSS22, BSSP-4, hBSSP-4, SP001LA, protease, serine 22, serine protease 22

External IDs

OMIM:609343;MGI:1918085;HomoloGene:23344;GeneCards:PRSS22;OMA:PRSS22 - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16p13.3	Start	2,852,730bp^[1]
Band	16p13.3	End	2,858,170bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17 A3.3\|17 12.18 cM	Start	24,212,508bp^[2]
Band	17 A3.3\|17 12.18 cM	End	24,217,074bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

olfactory zone of nasal mucosa

minor salivary glands

gallbladder

body of pancreas

right uterine tube

prostate

tonsil

vagina

right lobe of thyroid gland

left lobe of thyroid gland

Top expressed in

conjunctival fornix

transitional epithelium of urinary bladder

cornea

superior cervical ganglion

epithelium of lens

external carotid artery

esophagus

internal carotid artery

ciliary body

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	peptidase activity serine-type endopeptidase activity hydrolase activity serine-type peptidase activity
Cellular component	extracellular region extrinsic component of plasma membrane anchored component of plasma membrane
Biological process	proteolysis
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


64063


70835

Ensembl


ENSG00000005001 ENSG00000282937


ENSMUSG00000045027

UniProt


Q9GZN4


Q9ER10

RefSeq (mRNA)


NM_022119


NM_133731

RefSeq (protein)


NP_071402


NP_598492

Location (UCSC)

Chr 16: 2.85 – 2.86 Mb

Chr 17: 24.21 – 24.22 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Brain-specific serine protease 4 (BSSP-4), also known asserine protease 22 ortryptase epsilon, is anenzyme that in humans is encoded by thePRSS22gene.^[5]^[6]^[7]

This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16.^[5]

References

[edit]

^^a ^b ^cENSG00000282937 GRCh38: Ensembl release 89: ENSG00000005001, ENSG00000282937 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000045027 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^b"Entrez Gene: protease".
^Wong GW, Yasuda S, Madhusudhan MS, Li L, Yang Y, Krilis SA, Sali A, Stevens RL (December 2001)."Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells".J. Biol. Chem.276 (52):49169–82.doi:10.1074/jbc.M108677200.PMID 11602603.
^Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL (May 2005)."Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22".Blood.105 (10):3893–901.doi:10.1182/blood-2003-10-3501.PMC 1895090.PMID 15701722.

Clark HF, Gurney AL, Abaya E, et al. (2003)."The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment".Genome Res.13 (10):2265–70.doi:10.1101/gr.1293003.PMC 403697.PMID 12975309.
Martin J, Han C, Gordon LA, et al. (2004)."The sequence and analysis of duplication-rich human chromosome 16".Nature.432 (7020):988–94.Bibcode:2004Natur.432..988M.doi:10.1038/nature03187.PMID 15616553.
Mitsui S, Okui A, Kominami K, et al. (2005)."A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells".FEBS J.272 (19):4911–23.doi:10.1111/j.1742-4658.2005.04901.x.PMID 16176265.S2CID 25290079.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.

v t e Endopeptidases:serine proteases/serine endopeptidases (EC 3.4.21)
Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic
Coagulation	factors:Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis:Plasmin Plasminogen activator Tissue plasminogen activator Urinary plasminogen activator
Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase
Otherimmune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin
Venombin	Ancrod Batroxobin
Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin/S1P4 Sedolisin/TPP1 Streptokinase Cathepsin A G

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)