According toAlexander Shulgin in his bookTiHKAL (Tryptamines I Have Known and Loved) and other publications, PRO-LAD has a dose range of 100 to 200μg or 80 to 175μgorally and aduration of 6 to 8hours.[1][4][5][6] Theonset is within 15minutes.[1] It has around the samepotency as LSD, which has a listed dose range of 50 to 200μg.[1][4][5] On the other hand, PRO-LAD has a shorterduration than LSD, which has a listed duration of 8 to 12hours.[1][7]
The effects of PRO-LAD have been reported to include a lack ofvisuals and otherpsychedelic effects at lower doses, considerable visuals at higher doses,fantasy,synesthesia, clear thinking, lack of "cosmic-type" thinking, humor, pleasantness,dulled emotions, uncomfortableness,paranoia, andlightheadedness.[1] It has been described as having relatively light or moderate effects.[1] In addition, it is said to "not have any of the flavor of LSD", to be less visual than LSD, and to be "not up to LSD", if that is one's standard, as it is "basically not like LSD".[1][8]
PRO-LAD was first described in thescientific literature by Tetsukichi Niwaguchi and colleagues in 1976.[13] Subsequently, it was studied and described by Andrew J. Hoffman andDavid E. Nichols in 1985.[12] Thehallucinogenic effects of PRO-LAD in humans were first described by Nichols in aliterature review via personal communication withAlexander Shulgin in 1986.[8] The drug was later described in greater detail by Shulgin in his 1997 bookTiHKAL (Tryptamines I Have Known and Loved).[1] PRO-LAD is said to have been encountered as a noveldesigner drug by 2015.[14][15]
^Hassan Z, Bosch OG, Singh D, Narayanan S, Kasinather BV, Seifritz E, Kornhuber J, Quednow BB, Müller CP (2017)."Novel Psychoactive Substances-Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs".Front Psychiatry.8 152.doi:10.3389/fpsyt.2017.00152.PMC5563308.PMID28868040.Shulgin also described novel ergolines such as N-allyl-nor-lysergic acid diethylamide (AL-LAD), N-ethyl-nor-lysergic acid diethylamide (ETH-LAD), and N-propyl-nor-lysergic acid diethylamide (PRO-LAD) (200). These LSD-analogs are as potent as LSD (potency relative to LSD in human: AL-LAD: 110%, ETH-LAD: 140%, PRO-LAD: 90%), but AL-LAD and PRO-LAD have shorter duration of action (6–8 h) as ETH-LAD and LSD (both: 8–12 h) (189, 200).
^abNichols DE (February 1986). "Studies of the relationship between molecular structure and hallucinogenic activity".Pharmacol Biochem Behav.24 (2):335–340.doi:10.1016/0091-3057(86)90362-x.PMID3952123.
^abcHoffman AJ, Nichols DE (September 1985). "Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives".Journal of Medicinal Chemistry.28 (9):1252–1255.doi:10.1021/jm00147a022.PMID4032428.
^Schifano F, Papanti GD, Orsolini L, Corkery JM (July 2016). "Novel psychoactive substances: the pharmacology of stimulants and hallucinogens".Expert Rev Clin Pharmacol.9 (7):943–954.doi:10.1586/17512433.2016.1167597.hdl:2299/18468.PMID26985969.
^Wachełko O, Nowak K, Tusiewicz K, Zawadzki M, Szpot P (January 2025). "A highly sensitive UHPLC-MS/MS method for determining 15 designer LSD analogs in biological samples with application to stability studies".Analyst.150 (2):290–308.Bibcode:2025Ana...150..290W.doi:10.1039/d4an01361a.PMID39636448.
